Results 91 to 100 of about 30,747 (258)

Resolving tumor evolution: a phylogenetic approach

Journal of the National Cancer Center
The evolutionary dynamics of cancer, characterized by its profound heterogeneity, demand sophisticated tools for a holistic understanding. This review delves into tumor phylogenetics, an essential approach bridging evolutionary biology with oncology ...
Lin Li, Wenqin Xie, Li Zhan, Shaodi Wen, Xiao Luo, Shuangbin Xu, Yantong Cai, Wenli Tang, Qianwen Wang, Ming Li, Zijing Xie, Lin Deng, Hongyuan Zhu, Guangchuang Yu   +13 more
doaj   +1 more source

Complete mitochondrial genome and the phylogenetic position of the Lake Eyre hardyhead (Craterocephalus eyresii), a freshwater atherinid fish endemic to Lake Eyre Basin, South Australia

Mitochondrial DNA. Part B. Resources, 2017
The Lake Eyre hardyhead (Craterocephalus eyresii) is an endemic freshwater fish living in the Lake Eyre basin in South Australia. Here, I report the full mitogenome description and the phylogenetic position of this species based on the mitogenome ...
Davin H. E. Setiamarga
doaj   +1 more source

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

MFPD: A Multiple Fungal Pathogen Detection Pipeline Across Diverse Habitats

Advanced Science, EarlyView.
The MFPD pipeline integrates a comprehensive ITS reference database of fungal pathogens, optimized parameters, and algorithms tailored for both full‐length and subregion sequences that balance accuracy and computational efficiency; it enables high‐throughput, species‐level identification from amplicon sequencing data, supporting large‐scale ...
Yi Shen, Xinrun Yang, Jiabao Yu, Yaozhong Zhang, Tianjie Yang, Yang Gao, Xiaofang Wang, Alexandre Jousset, Waseem Raza, Fang‐Jie Zhao, Qirong Shen, Gaofei Jiang, Zhong Wei, Yangchun Xu   +13 more
wiley   +1 more source

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

Polychip‐A High‐Throughput Droplet Microfluidics Platform for Interrogating Microbial Interactions

Advanced Science, EarlyView.
Polychip, a fully integrated droplet microfluidics platform, enables high‐throughput, single‐cell resolution screening of polymicrobial interactions. By seamlessly combining six automated microfluidics operations on a single chip, the system accelerates antimicrobial discovery by 11 to 14 times compared to traditional robotic methods.
Jeong Jae Han, Adrian Ryan Guzman, Aifen Zhou, Han Zhang, Rohit Gupte, Haemin Jung, Kaylee Delgado, Sini Skariah, Ali Sultan, Arul Jayaraman, Paul de Figueiredo, Arum Han   +11 more
wiley   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Discovery and Engineering of a Rat Endogenous Retrovirus Reverse Transcriptase for Efficient Prime Editing

Advanced Science, EarlyView.
We screened 558 reverse transcriptases and engineered an optimized rat endogenous retrovirus‐derived variant, enRERV‐RT, via structure‐guided engineering and deep mutational scanning. This enhanced prime editor, based on the engineered RT, outperforms conventional M‐MLV‐RT systems across plant and animal cells, particularly at hard‐to‐edit loci ...
Linsha Ma, Pengcheng Yao, Shengqi Wu, Yuanyuan Shi, Lang Qin, Baitao Li, Jiayi Zhu, Minhua Huang, Yichong Zhu, Yuwen Song, Jinhuan Pang, Ziping Guo, Guochuan Wu, Chen Wang, Kewei Xu, Ruihua Huang, Quan Kuang, Liang Qu, Changtian Pan, Xianrong Xie, Qinlong Zhu, Jiaying Huang, Qiupeng Lin   +22 more
wiley   +1 more source

Phylogenetics

Scholarpedia, 2008
J. Howard Frank, J. Howard Frank, Michael C. Thomas, Allan A. Yousten, F. William Howard, Robin M. Giblin-davis, John B. Heppner, Robert L. Zuparko, Norma E. Sánchez, María G. Luna, Marta Goula, John B. Heppner, Andrey N. Alekseev, Rosalind R. James, John L. Capinera, Phyllis G. Weintraub, David Horton, J. Howard Frank, Kenneth W. Mccravy, David G. Riley, David C. Marshall, Cyrus Abivardi, Marjorie A. Hoy, Efat M. Abou-fakhr hammad, Jason G. Froeba, David Legg, Heather J. Mc Auslane, Qiao Wang, Cyrus Abivardi, Seth Bybee, Menachem J. Berlinger, Sarah Lebiush-mordechi, Harold A. Denmark, J. Howard Frank, Whitney Cranshaw, John L. Capinera, John B. Heppner, Chris Asaro, Erik Christiansen, William J. Roltsch, Dale E. Meyerdirk, Lewis B. Coons, Marjorie Rothschild, Minos E. Tzanakakis, Pauline O. Lawrence, Alfred G. Wheeler, Thomas J. Henry, Russell F. Mizell, Partricia A. Mizell, John B. Heppner, Lois B. O’ brien, Menachem J. Berlinger, Anthony Rossi, Wayne B. Hunter, Charles Vincent, Gérald Chouinard, Tracy Leskey, Deborah L. Matthews, Peter G. Kevan, Antonio Felicioli, Mauro Pinzauti, Olle Pellmyr, John T. Trumble, Danel B. Vickerman, Cyrus Abivardi, Robert McSorley, K. K. Verma, John L. Capinera, Peter H. Adler, Igor Uspensky, Donald W. Hall, John L. Capinera, Juan M. Alvarez, John L. Capinera, Eugene J. Gerberg, Lawrence E. Hurd, Lawrence E. Hurd, Patrick De Clercq, John B. Heppner, J. Howard Frank, Lawrence I. Gilbert, Robert Rybczynski, Christopher Tipping, James H. Tsai, Philip Weinstein, David Slaney, Peter H. Adler, Zeyaur R. Khan, John A. Pickett, John B. Heppner, Cyrus Abivardi, Katie Goodman, Kenneth W. McCravy, Andrei Sourakov   +93 more
openaire   +2 more sources

Pemt Inhibition‐Mediated Vdac1 Oligomerization Regulates Mitochondrial Dysfunction, Apoptosis, and Inflammation in High‐Fat Diet‐Derived Liver Injury

Advanced Science, EarlyView.
ABSTRACT High‐fat diet (HFD)‐induced hepatic injury represents a pathology observed across vertebrates, yet the underlying mechanisms remain incompletely understood. Herein, the present study identifies phosphatidylethanolamine methyltransferase (Pemt), a key enzyme in phosphatidylcholine synthesis, as a critical regulator of mitochondrial homeostasis ...
Xianyong Bu, Xiufei Cao, Xin Yao, Baolin Li, Wencong Lai, Zengqi Zhao, Tingting Hao, Zhiwei Chen, Jianlong Du, Yueru Li, Kangsen Mai, Qinghui Ai   +11 more
wiley   +1 more source