Dissecting Pirtobrutinib Resistance in Mantle Cell Lymphoma Through Single‐Cell Multi‐Omics
American Journal of Hematology, EarlyView.ABSTRACT Pirtobrutinib (PBN), a non‐covalent BTK inhibitor, has been approved by the FDA for relapsed/refractory mantle cell lymphoma (MCL); however, resistance to PBN has been observed. To dissect the molecular dynamics driving PBN resistance, we performed integrative single‐cell multi‐omic profiling (scRNA‐seq, scATAC‐seq, and scDNA‐seq) on ...
Fangfang Yan +10 more
wiley +1 more source
Systematics of the endemic Pleistocene deer of Mediterranean islands [PDF]
, 2013 Breda, Marzia +2 more
core +1 more source
Circulating Tumor Cells in Multiple Myeloma: From Peripheral Clues to Central Insights
American Journal of Hematology, EarlyView.CTC offer a minimally invasive widow into systemic myeloma biology, overcoming the sampling bias of bone marrow biopsies. Their prognostic value at diagnosis, potential role in MRD monitoring, and ability to capture clonal evolution highlight them as actionable biomarkers for future precision medicine.
Benjamin Podvin +3 more
wiley +1 more source
A Mitilanotherium (Artiodactyla: Giraffidae) skull from the Lower Pleistocene locality of Sésklo (SE Thessaly, Greece) [PDF]
, 2013 Athanassiou, Athanassios +1 more
core +1 more source
Animal Models and Experimental Medicine, EarlyView.Diabetes combined with ischemic stroke (DMIS) exacerbates brain infarct size and neuronal damage compared to nondiabetic ischemic stroke (IS). This study reveals that microRNA‐34a (miR‐34a) plays a key role in DMIS pathogenesis: miR‐34a directly targets and suppresses brain‐derived neurotrophic factor (BDNF) and Sine oculis homeobox 3 (SIX3), promoting
Ling Zhao +5 more
wiley +1 more source
New Late Miocene North American dromomerycine artiodactyl from the Amazon Basin: implications for interchange dynamics [PDF]
, 2013 Beatty, Brian L. +4 more
core +1 more source
A revision of cervid phylogeny using a total evidence approach [PDF]
, 2013 Asher, Robert J. +4 more
core +1 more source
On the phylogenetic position of the hornless pecoran Amphimoschus – an example of arising challenges with the incorporation of fossils in extant combined frameworks [PDF]
, 2013 Asher, Robert J. +6 more
core +1 more source