Results 141 to 150 of about 620,319 (331)

A preliminary phylogeographic study of Flavopunctelia and Punctelia inferred from rDNA ITS-sequences [PDF]

open access: yes, 2005
A preliminary phylogeny of the genera Flavopunctelia and Punctelia is presented. Genus and species delimitations have been investigated using ITS rDNA-sequencing of populations from different continents.
Adler, Monica Teresa   +5 more
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Distribution and genetic variability of Staphylinidae across a gradient of anthropogenically influenced insular landscapes [PDF]

open access: yes, 2016
This paper describes the distribution and genetic variability of rove beetles (Coleoptera Staphylinidae) in anthropogenically influenced insular landscapes.
Borges, Paulo A. V.   +5 more
core  

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

The complete mitochondrial genome of the deep-sea paskentanid snail Alviniconcha marisindica (Caenogastropoda: abyssochrysoidea) from the Carlsberg Ridge

open access: yesMitochondrial DNA. Part B. Resources
Alviniconcha marisindica Okutani 2014 is a deep-sea gastropod inhabited in hydrothermal vents of the Indo-Pacific. It belongs to superfamily Abyssochrysoidea. In the present study, we report the complete mitochondrial genome of A.
Mei Yang   +4 more
doaj   +1 more source

Introduction of Fusarium sp. UTMC 5039 as a potent fungal strain for biosurfactant production and evaluation of its potential for crude oil bioremediation [PDF]

open access: yesBiological Journal of Microorganism, 2017
Introduction: Biosurfactants are biological surface active agents which are used in many applications such as oil bioremediation of contaminated soils.
Hamid Moghimi   +4 more
doaj  

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

open access: yesMolecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

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