Results 171 to 180 of about 445,514 (353)
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Phylogeography of lagenorhynchus acutus and lagenorhynchus albirostris and phylogeny of the genus lagenorhynchus [PDF]
, 2008 This study had two main objectives: to clarify the phylogenetic position of the species cuiTently classified in the genus L igenorhynchus, using a ทานItilocus phylogenetic approach; and to understand the evolutionary history, population structure and ...
Banguera Hinestroza, Eualia
core
Taxonomy And Phylogeny Of Dothideomycetes
, 2014 Mckenzie, Eric, Jones, E.B. Gareth, Hyde, Kevin, Mckenzie, Editorial-Taxonomy And Phylogeny Of Dothideomycetes Eric H.C., Jones, E.B. Gareth, Hyde, Kevin D., Ariyawansa, Hiran A., Thambugala, Kasun M., Kang, Ji-Chuan, Alias, Siti A., Chukeatirote ...
Hyde, Kevin D. +9 more
core +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Systematic studies of the South African Campanulaceae sensu stricto with and emphasis on generic delimitations [PDF]
, 2009 The South African Campanulaceae sensu stricto, comprising 10 genera, represent the most diverse lineage of the family in the southern hemisphere. In this study two phylogenies are reconstructed using parsimony and Bayesian methods.
Cupido, Christopher Nelson
core
Frontiers in Public HealthThe polioviruses (PVs) are mainly transmitted by direct contact with an infected person through the fecal-oral route and respiratory secretions (or more rarely via contaminated water or food) and have a primary tropism for the gut.
Christian Albert Devaux +6 more
doaj +1 more source
FEBS Open Bio, EarlyView.The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura +19 more
wiley +1 more source