Heliyon, 2023 Objective To explore the mechanism of PG against acute lymphoblastic leukaemia (ALL) by network pharmacology and experimental verification in vitro. Methods First, the biological activity of PG against B-ALL was determined by CCK-8 and flow cytometry ...
Jing Liu +5 more
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Characterization and Mechanism Prediction of Active Components in Fuganlin Oral Liquid for Respiratory Tract Infections Using UPLC-Q-TOF-MS and Network Pharmacology. [PDF]
J Anal Methods ChemFuganlin oral liquid (FOL) has been clinically employed for the treatment of pediatric qi deficiency colds, manifesting symptoms such as fever, cough, asthma, and sore throat. However, the chemical composition and bioactive components of FOL have not been clearly elucidated.
Zhang M +7 more
europepmc +2 more sources
Frontiers in Pharmacology, 2022 Liver cancer is a global disease with a high mortality rate and limited treatment options. Alternations in apoptosis of tumor cells and immune cells have become an important method for detailing the underlying mechanisms of hepatocellular carcinoma (HCC).
Huanyu Jiang +4 more
doaj +1 more source
Development and Validation of a SPE-HPLC Method for Quantification of Rhein, Emodin, Chrysophanol and Physcion in Rhamnus petiolaris Boiss. & Balansa. [PDF]
J Chromatogr Sci, 2023 Anthraquinones exhibit a significant group of natural and synthetic quinone derivatives because of their biological activities and industrial applications. Rhamnaceae is one of the families known to contain different kinds of anthraquinones.
Köseoğlu Yılmaz P, Kolak U.
europepmc +2 more sources
ACS Omega, 2023 This study aims to enhance the dissolution rate of a poorly water-soluble drug physcion by producing its nanoparticles (NPs) using an antisolvent precipitation with a syringe pump (APSP) method and to assess its antioxidant and cytotoxic potential.
Fazli Khuda +9 more
semanticscholar +1 more source
Qishiwei Zhenzhu Pills Protect Against Cerebral Ischemia via the P53/Cytochrome C/Apoptotic Protease Activating Factor 1-Mediated Mitochondrial Apoptosis Pathway. [PDF]
CNS Neurosci TherUltra‐high performance liquid chromatography with quadrupole time‐of‐flight mass spectrometry was used for qualitative and metabolomic analysis of the distribution of Qishiwei Zhenzhu pills’ (QSWZZP, Tibetan name: རཏྣ་བསམ་འཕེལ།) components in the blood and tissues.
Song Y +12 more
europepmc +2 more sources
European Journal of Science and Technology, 2021 In this study, a reverse-phase high performance liquid chromatography (RP-HPLC) method with high separation efficiency, high detection sensitivity and excellent selectivity was successfully developed for the simultaneous determination of the aloe-emodin,
Gizem Yıldırım Baştemur +3 more
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Physcion prevents induction of optic nerve injury in rats via inhibition of the JAK2/STAT3 pathway
Experimental and Therapeutic Medicine, 2023 Optic nerve injury is a type of neurodegenerative disease. Physcion is an anthraquinone that exerts a protective role against various diseases. However, its function in regulating optic nerve injury remains largely unknown.
Jingjing Li +6 more
semanticscholar +1 more source
Stepwise pH-Gradient elution for the preparative separation of natural anthraquinones by multiple liquid-liquid partition [PDF]
, 2001 Peer ...
Hynninen, Paavo H., Räisänen, Riikka
core +1 more source
Transcriptomic analysis reveals distinct resistant response by physcion and chrysophanol against cucumber powdery mildew [PDF]
PeerJ, 2016 Physcion and chrysophanol induce defense responses against powdery mildew in cucumbers. The combination of these two compounds has synergistic interaction against the disease.
Yanping Li +5 more
doaj +2 more sources