Results 1 to 10 of about 12,407 (222)

The Comparison of the Efficiency of Emodin and Aloe-Emodin in Photodynamic Therapy

International Journal of Molecular Sciences, 2022
Skin cancer (melanoma and non-melanoma) is the most frequent type of malignancy in the Caucasian population. Photodynamic therapy (PDT) as an interesting and unique strategy may potentially boost standard therapeutic approaches. In the present study, the potential of emodin and aloe-emodin as photosensitizers in photodynamic therapy has been ...
Marta Wozniak, Mariusz A Bromke, Piotr Ziolkowski   +2 more
exaly   +5 more sources

Nanoparticle-Mediated Delivery of Emodin via Colonic Irrigation Attenuates Renal Injury in 5/6 Nephrectomized Rats

Frontiers in Pharmacology, 2021
Our previous study showed that emodin enema modulates gut microbiota and delays CKD progression. However, the poor solubility, limited colonic irrigation retention time, and inadequate colon adhesion of emodin hinder its clinical application.
Zhaoyu Lu, Zhaoyu Lu, Chunlan Ji, Chunlan Ji, Xuewen Luo, Yong Lan, Lijuan Han, Yang Chen, Xusheng Liu, Qinzhan Lin, Fuhua Lu, Xiuqing Wu, Rui Guo, Chuan Zou   +13 more
doaj   +1 more source

Emodin inhibits invasion and migration of hepatocellular carcinoma cells via regulating autophagy-mediated degradation of snail and β-catenin

BMC Cancer, 2022
Background Previous studies reported that emodin extracted from Rheum palmatum L. exerts antiproliferation and antimetastatic effects in a variety of human cancer types.
Binyu Qin, Zhili Zeng, Jianliang Xu, Jing Shangwen, Zeng Jie Ye, Shutang Wang, Yanheng Wu, Gongfeng Peng, Qi Wang, Wenyi Gu, Ying Tang   +10 more
doaj   +1 more source

Emodin reverses leukemia multidrug resistance by competitive inhibition and downregulation of P-glycoprotein. [PDF]

PLoS ONE, 2017
Development of multidrug resistance (MDR) is a continuous clinical challenge partially due to the overexpression of P-glycoprotein (P-gp) for chronic myelogenous leukemia (CML) patients.
Hongping Min, Miaomiao Niu, Weilin Zhang, Jia Yan, Jiachang Li, Xiying Tan, Bo Li, Mengxiang Su, Bin Di, Fang Yan   +9 more
doaj   +1 more source

Adsorption Characteristics and Enrichment of Emodin from Marine-Derived Aspergillus flavipes HN4-13 Extract by Macroporous Resin XAD-16

Marine Drugs, 2022
Emodin, a hydroxyanthraquinone derivative, has been used as medicine for more than 2000 years due to its extensive pharmacological activities. Large-scale production of emodin has been achieved by optimizing the fermentation conditions of marine-derived ...
Lizhi Gong, Yuzhen Wu, Xiaohan Qiu, Xiujuan Xin, Faliang An, Miaomiao Guo   +5 more
doaj   +1 more source

Advances in the mechanism of emodin-induced hepatotoxicity

Heliyon
Emodin is a naturally occurring anthraquinone derivative and serves as an active component in various traditional Chinese herbal medicines. It is widely known for its broad pharmacological effects, including anti-inflammatory, antioxidant, and anticancer
Yupeng Wang, Mengchao Zhao, Bo Li, Xingchao Geng   +3 more
doaj   +3 more sources

Emodin regulates cell cycle of non-small lung cancer (NSCLC) cells through hyaluronan synthase 2 (HA2)-HA-CD44/receptor for hyaluronic acid-mediated motility (RHAMM) interaction-dependent signaling pathway

Cancer Cell International, 2021
Background Non-small cell lung cancers (NSCLC) account for most cases of lung cancer. More effort is needed to research new drug and combination therapies for this disease. An anthraquinone derivative, emodin shows anticancer potency.
Mingzhu Li, Shengbo Jin, Yang Cao, Jian Xu, Shendong Zhu, Zheng Li   +5 more
doaj   +1 more source

Emodin prevents renal ischemia-reperfusion injury via suppression of p53-mediated cell apoptosis based on network pharmacology

Heliyon, 2023
Background: Previous evidence indicated that emodin has significant advantages for preventing acute kidney injury (AKI). However, the mechanisms responsible for these effects of emodin have yet to be elucidated.
Hongmei Lu, Dengpiao Xie, Bo Qu, Mingquan Li, Yuhua He, Weijing Liu   +5 more
doaj   +1 more source

Emodin attenuates high lipid-induced liver metastasis through the AKT and ERK pathways in vitro in breast cancer cells and in a mouse xenograft model

Heliyon, 2023
Emodin, a natural anthraquinone derivative, can inhibit lipid synthesis and breast cancer cell proliferation. We previously found that emodin decreased breast cancer liver metastasis via epithelial-to-mesenchymal transition (EMT) inhibition. However, the
Feng Li, Xiaoyun Song, Xiqiu Zhou, Lili Chen, Jinzhou Zheng   +4 more
doaj   +1 more source

Emodin alleviates lung ischemia–reperfusion injury by suppressing gasdermin D‐mediated pyroptosis in rats

The Clinical Respiratory Journal, 2023
Background Pyroptosis refers to programmed cell death associated with inflammation. Emodin has been reported to alleviate lung injuries caused by various pathological processes and attenuate ischemia–reperfusion (I/R) injuries in diverse tissues. Methods
Tao Jin, Fen Ai, Jin Zhou, Lin Kong, Zhangming Xiong, Dingping Wang, Ruilin Lu, Zhen Chen, Muxi Zhang   +8 more
doaj   +1 more source