Results 31 to 40 of about 12,407 (222)

Ascorbate-and iron-driven redox activity of Dp44mT and emodin facilitates peroxidation of micelles and bicelles

, 2021
BACKGROUND: Iron (Fe)-induced oxidative stress leads to reactive oxygen species that damage biomembranes, with this mechanism being involved in the activity of some anti-cancer chemotherapeutics. METHODS: Herein, we compared the effect of Fe complexes of
Bernhardt, PV, Afroz, R, Richardson, DR, Polyakov, NE, Koshman, VE, Selyutina, O Yu, Azad, M Gholam, Shelepova, EA, Kononova, PA, Dharmasivam, M   +9 more
core   +1 more source

Aloe-Emodin Induces Mitochondrial Dysfunction and Pyroptosis by Activation of the Caspase-9/3/Gasdermin E Axis in HeLa Cells

Frontiers in Pharmacology, 2022
Aloe-emodin (1,8-dihydroxy-3-hydroxymethyl-anthraquinone), derived from some Chinese edible medicinal herbs, exerts a potential anticancer activity on various cancer cells, making it a drug candidate for cancer therapy.
Tonghui Li, Tonghui Li, Liuliu Shi, Wenqiang Liu, Xuhao Hu, Yuanjian Hui, Maojun Di, Shen Xue, Yan Zheng, Yan Zheng, Mengjuan Yao, Chen Li, Chen Li, Kun Meng, Kun Meng   +14 more
doaj   +1 more source

Therapeutic Potential of Emodin for Gastrointestinal Cancers [PDF]

Integrative Cancer Therapies, 2022
Gastrointestinal (GI) cancers cause one-third of all cancer-related deaths worldwide. Natural compounds are emerging as alternative or adjuvant cancer therapies given their distinct advantage of manipulating multiple pathways to both suppress tumor growth and alleviate cancer comorbidities; however, concerns regarding efficacy, bioavailability, and ...
Sierra J. McDonald, Brandon N. VanderVeen, Kandy T. Velazquez, Reilly T. Enos, Ciaran M. Fairman, Thomas D. Cardaci, Daping Fan, E. Angela Murphy   +7 more
openaire   +3 more sources

Emodin Down-Regulates Expression of TRPV1 mRNA and Its Function in DRG Neurons in Vitro [PDF]

, 2010
Emodin is a principle ingredient isolated from rhubarb rhizome, which is commonly used for constipation or pain-related diseases in traditional Chinese medicine (TCM) practice. The transient receptor potential vanilloid 1 ion channel proteins (TRPV1) are
Zhao, Bao-Sheng, Jiang, Ting-Liang, Sui, Feng, Zhang, Chang-Bin, Yang, Na, Liu, Hong-Bin, Li, Lan-Fang, Huo, Hai-Ru, Guo, Shu-Ying, T.L.Jiang, Du, Xin-Liang, Guo, Jian-You   +11 more
core   +1 more source

Emodin Alleviates Lupus Nephritis in Rats by Regulating M1/M2 Macrophage Polarization

Journal of Chemistry, 2023
Lupus nephritis (LN) is one of the most common clinical manifestations of systemic lupus erythematosus (SLE), causing death and disability. The current research study explored whether there was any improvement effect on LN after emodin administration ...
Weijian Xiong, Ying Li, Ling Zhang, Yanying Xiong, Jin Zhong, Xunjia Li, Yan Luo, Hong Liu, Renhong Kang, Yunjie Chen   +9 more
doaj   +1 more source

RETRACTED: Emodin Interferes With AKT1-Mediated DNA Damage and Decreases Resistance of Breast Cancer Cells to Doxorubicin

Frontiers in Oncology, 2021
Doxorubicin (DOX) is a cytotoxic drug used for the treatment of breast cancer (BC). However, the rapid emergence of resistance toward doxorubicin threatens its clinical application, thus the need for combination therapy.
Bo Li, Xin Zhao, Lei Zhang, Wen Cheng
doaj   +1 more source

Magnetic Bead-Based Ligand Fishing Identifies SARS-CoV-2 Main Protease Inhibitors From Reynoutria japonica. [PDF]

Chem Biodivers
A magnetic bead‐based ligand fishing workflow using immobilized SARS‐CoV‐2 Mpro was coupled with UPLC‐Q‐Exactive‐Orbitrap‐MS/MS to screen potential Mpro‐binding constituents directly from a crude Reynoutria japonica extract. Eight compounds were captured and annotated, of which six showed concentration‐dependent Mpro inhibition, with resveratrol ...
Huang Y, Tian C, Gu Z, Liang J, Zu D, Yang J, Zhang W, Ren N, Zheng J.   +8 more
europepmc   +2 more sources

The p53-mediated cell cycle regulation is a potential mechanism for emodin-suppressing osteosarcoma cells

Heliyon
Background: As the most common primary bone cancer, the therapy of osteosarcoma requires further study. An anthraquinone derivative, emodin, has been found to have anticancer potential.
Qian Zhang, Shuli Hao, Guangyou Wei, Xiangyu Liu, Yang Miao   +4 more
doaj   +1 more source

Emodin-induced autophagic cell death hinders epithelial–mesenchymal transition via regulation of BMP-7/TGF-β1 in renal fibrosis

Journal of Pharmacological Sciences, 2021
We aim to explore the effects of emodin and its mechanisms on renal fibrosis (RF). We firstly modeled adriamycin-induced rat RF with unilateral nephrectomy. In vivo and in vitro pharmacological experiments were performed in this study.
Wei Liu, Renze Gu, Yujiao Lou, Chunfeng He, Qingchuan Zhang, Dongmei Li   +5 more
doaj   +1 more source

Emodin alleviates cardiac fibrosis by suppressing activation of cardiac fibroblasts via upregulating metastasis associated protein 3

Acta Pharmaceutica Sinica B, 2019
Excess activation of cardiac fibroblasts inevitably induces cardiac fibrosis. Emodin has been used as a natural medicine against several chronic diseases.
Dan Xiao, Yue Zhang, Rui Wang, Yujie Fu, Tong Zhou, Hongtao Diao, Zhixia Wang, Yuan Lin, Zhange Li, Lin Wen, Xujuan Kang, Philipp Kopylov, Dmitri Shchekochikhin, Yong Zhang, Baofeng Yang   +14 more
doaj   +1 more source