Results 51 to 60 of about 12,407 (222)
Phytotherapy Research, EarlyView.ABSTRACT Obesity is a major risk factor for type 2 diabetes. Some traditional Chinese medicine (TCM) compounds can improve obesity by increasing energy consumption. This study aimed to identify and verify TCM compounds that promote adipose thermogenesis to alleviate obesity via transcriptomic analysis, molecular docking, network pharmacology, and ...
Jing Li +6 more
wiley +1 more source
Emodin downregulates androgen receptor and inhibits prostate cancer cell growth [PDF]
, 2009 [[abstract]]Hormone-refractory relapse is an inevitable and lethal event for advanced prostate cancer patients after hormone deprivation. A growing body of evidence indicates that hormone deprivation may promote this aggressive prostate cancer phenotype.
Cha, T-L.;Qiu, L.;Chun-Te Chen;Wem, Y;Mien-Chie Hung
core
Aloe-emodin induces apoptosis in human oral squamous cell carcinoma SCC15 cells
BMC Complementary and Alternative Medicine, 2018 Background Oral and pharyngeal cancer is the most common malignant human cancers. Chemotherapy is an effective approach for anti-oral cancer therapy, while the drug tolerance and resistance remain a problem for oral cancer patients.
Qihong Li +7 more
doaj +1 more source
The Chemical Structure and the Mutagenicity of Emodin Metabolites [PDF]
Agricultural and Biological Chemistry, 1990 Emodin (1,3,8-trihydroxy-6-methyl-9,10-anthraquinone) is a natural occurring anthraquinone formed in rhubarb and fungal metabolites. Emodin was transformed into 6 major metabolites by rat hepatic microsomes. The metabolites were identified as 2-hydroxyemodin, 4-hydroxyemodin, 5-hydroxyemodin, 7-hydroxyemodin, ω-hydroxyemodin, and emodic acid by ...
MOROOKA, Nobuhisa +3 more
openaire +2 more sources
Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events
Phytotherapy Research, EarlyView.An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia +1 more
wiley +1 more source
Phytotherapy Research, EarlyView.The translational research framework integrating TCM for RA. The figure outlines a stepwise framework for the modernization and clinical translation of TCM in RA. Part 1 highlights the inheritance and development of TCM theory, including classical medical texts, traditional herbal knowledge, and syndrome differentiation–based treatment principles. Part
Jianting Wen +4 more
wiley +1 more source
Neuroprotection of Emodin by Inhibition of Microglial NLRP3 Inflammasome-Mediated Pyroptosis
Journal of Integrative Neuroscience, 2023 Background: Neuroinflammation triggered by chronic cerebral ischemia-induced microglial pyroptosis is a significant contributor to vascular cognitive impairment.
Wen Jiang +7 more
doaj +1 more source
Phytotherapy Research, EarlyView.Pancreatic cancer, particularly pancreatic ductal adenocarcinoma, is aggressive and often diagnosed late, making treatment challenging. This review highlights the potential of phytochemicals, such as curcumin and quercetin, as multitarget agents that influence key carcinogenic pathways. These compounds exhibit anticancer effects by inhibiting processes
Md. Rezaul Islam +7 more
wiley +1 more source
Emodin inhibits colon cancer by altering BCL-2 family proteins and cell survival pathways
Cancer Cell International, 2019 Background Currently offered therapeutics to treat colon cancer (CoCa) are toxic when given at maximum tolerated dose to achieve optimal clinical response. Hence, less toxic therapeutic intervention is needed to treat CoCa. In this study, we investigated
Ian T. Saunders +3 more
doaj +1 more source