Results 101 to 110 of about 6,166,838 (247)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Funding Accessibility Projects: In Search of the Money Tree [PDF]

, 2004
A brief technical report on accessibility fundingNational Center on Physical Activity and Disability Centers for Disease Control and ...
Shrake, Amy
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Availability and affordability of diabetes healthcare services associated with the frequency of diabetes-related complications

BMC Health Services Research
Aims Understanding the healthcare access challenges facing diabetic patients in low- and middle-income countries is very important. The present study investigated the association between availability (physical access) and affordability (economic access ...
Mehran Alijanzadeh, Sima Hashemipour, Fereshteh Attaran, Samira Saremi, Leila Modarresnia, Hamidreza Ghafelehbashi, Mark D. Griffiths, Zainab Alimoardi   +7 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Content Accessibility of Web documents. Principles and Recommendations [PDF]

The paper is an overview of issues related to the accessibility of Web sites, of European initiatives and recommendations in the field, of future solutions, such as developing Web 2.0 accessible applications with WAI-ARIA.
Elena JITARU, Adriana ALEXANDRU
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Comparing physical education course satisfaction between students with hearing and visual impairments in Mainland China: a revised importance—Performance analysis

Frontiers in Psychology
IntroductionThis study examined physical education satisfaction among Chinese university students with hearing and visual impairments using Revised Importance-Performance Analysis (RIPA).MethodsA cross-sectional survey was conducted with 449 students ...
Lihua Cui, Wenpeng Zhan
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Accessibility of Urban Transport for People with Disabilities and Limited Mobility : Lessons from East Asia and the Pacific

, 2012
Accessibility of transport is not always a priority in transport planning and implementation. There can be barriers in the physical environment and delivery of services that render transport inaccessible.
Babinard, Julie, Wang, Wei, Bennett, Christopher R., Mehndiratta, Shomik   +3 more
core   +1 more source