Results 111 to 120 of about 6,166,838 (247)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

“True” Accessibility Barriers of Heritage Buildings

Buildings
Heritage buildings, which symbolize the pride of a nation, were built prior to the development of current standards, including those for accessibility. As nations strive for equity, diversity, and inclusion, creating barrier-free environments, including ...
Samir E. Chidiac, Mouna A. Reda
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Integrating Streetscape Images, Machine Learning, and Space Syntax to Enhance Walkability: A Case Study of Seongbuk District, Seoul

Land
As urbanization rapidly progresses, streets have transitioned from mere transportation corridors to crucial spaces for daily life and social interaction. While past research has examined the impact of physical street characteristics on walkability, there
Zhongshan Huang, Bin Wang, Shixian Luo, Manqi Wang, Jingjing Miao, Qiyue Jia   +5 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Leaders Like Us: Supporting Inclusivity and Accessibility in Female Physical Activity Leadership

Baltic Journal of Sport and Health Sciences
Background: The United Kingdom physical activity workforce remains predominantly White and male, contributing to lower participation rates among young females from underserved communities.
Jamie Crowther, Jennifer Hall
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Physical presence, practical absence: Accessibility of timber inventory in the eastern US

Trees, Forests and People
Forest resources in the eastern US are located on heterogeneous landscapes with widely varying biophysical, social, and market characteristics. As such, the total inventory is rarely available for harvest within a region.
Gaurav Dhungel, Justin Baker, Jesse D. Henderson   +2 more
doaj   +1 more source

Development and Application of an Activity Based Space-Time Accessibility Measure for Individual Activity Schedules [PDF]

Accessibility is an important aspect of human existence impacting on our notion of society equity and justice. It plays an important role in a number of existing theories of spatial and travel behaviour in addition to affecting the rate and the pattern ...
Olu Ashiru, John Polak, Robert B. Noland
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