Results 61 to 70 of about 6,166,838 (247)

Mapping Accessibility Over Time [PDF]

The concept of "accessibility" has been coin in the transportation planning field for more than 40 years. Improving accessibility is a common element in the goals section in almost all transportation plans in the US.
Ahmed El-Geneidy, David Levinson
core  

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Accessibility and the Journey to Work [PDF]

This study analyzes the effect of accessibility to jobs and houses at both the home and work ends of trips on commuting duration for respondents to a household travel survey in metropolitan Washington, DC.
David Levinson
core  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Perceptions from people with physical disabilities about accessibility and social conditions: interventions for rehabilitation nursing [PDF]

Revista Brasileira de Enfermagem
Objectives: to analyze the experiences of people with acquired physical disabilities regarding accessibility and social conditions; to identify nurse-led rehabilitation interventions for accessibility and social conditions; to determine nursing-sensitive
Rute Salomé da Silva Pereira, Salomé Sobral Sousa, Maria Manuela Martins, Wiliam César Alves Machado, Soraia Dornelles Schoeller   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Using open accessibility data for accessible travelling

, 2014
This paper summarizes the research of using open accessibility data for accessible travelling. With the aim of addressing the gap between users’ special needs and complex accessibility barriers in real world, we proposed a personalized accessible ...
Ding, Chaohai, Wald, Mike, Wills, Gary
core   +1 more source

IceQream: Quantitative chromosome accessibility analysis using physical TF models

Nature Communications
Single-cell mapping of chromosomal accessibility patterns has recently led to improved predictive modelling of epigenomic activity from sequence. However, quantitative models explaining the epigenome using directly interpretable components are still ...
Akhiad Bercovich, Aviezer Lifshitz, Michal Eldar, Saifeng Cheng, Roni Stok Ranen, Yonatan Stelzer, Amos Tanay   +6 more
doaj   +1 more source

Reasoning with alternative explanations in physics: The cognitive accessibility rule

Physical Review Physics Education Research, 2018
A critical component of scientific reasoning is the consideration of alternative explanations. Recognizing that decades of cognitive psychology research have demonstrated that relative cognitive accessibility, or “what comes to mind,” strongly affects ...
Andrew F. Heckler, Abigail M. Bogdan
doaj   +1 more source