Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Economic and physical food accessibility in the Czech Republic
, 2016 The paper focuses on the analysis of economic and physical accessibility and availability of food in the Czech Republic. Food security includes three main pillars - availability, access, and utilisation.
Lukášková, Eva +2 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Physical accessibility, availability, financial affordability, and acceptability of mobile health clinics in remote areas of Saudi Arabia. [PDF]
J Family Med Prim Care, 2023 Balharith M +6 more
europepmc +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Environmental and personal factors that influence gym members with disabilities
Advanced Exercise and Health ScienceIndividuals with disabilities (IWD) are at increased risk for chronic health conditions. Much of this risk can be countered through exercise, yet most IWD do not achieve enough exercise to meet recommended guidelines.
Cassandra M. Beattie +2 more
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Transport equity and COVID-19: a systematic review of accessibility and policy implications
European Transport Research ReviewThe COVID-19 pandemic and its containment measures have significantly impacted both physical and virtual accessibility, disproportionately affecting disadvantaged populations and exacerbating transport inequities.
Xi Feng +5 more
doaj +1 more source
Disparities in Physical Accessibility among Rural Thais Under Universal Health Coverage. [PDF]
Am J Trop Med Hyg, 2021 Rojjananukulpong R, Ahmad MM, Saqib SE.
europepmc +1 more source