Results 131 to 140 of about 13,180,176 (302)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Student Physical Activity Behaviour – Executive Summary [PDF]

Physical activity is now recognised world wide as an important contributor to general health and well being of the population as a whole, regardless of age, gender or ethnicity.
Lewis, Kiara, Sellars, Chris
core   +2 more sources

Global spinal mobility shows no consistent association with trunk strength in children: a school-based cross-sectional study

Frontiers in Sports and Active Living
BackgroundGiven the high prevalence of low back pain from adolescence, this study examined whether global spinal mobility is associated with trunk strength in healthy schoolchildren.ObjectiveTo quantify global spinal mobility and movement speed, trunk ...
Julio Martín-Ruiz, Concepción Ros-Ros, Clara Gallego-Cerveró, Laura Ruiz-Sanchis   +3 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Examining the role of school food gardens, food waste systems and cooking facilities in experiential education: a cross-sectional survey of primary school teachers’ practices

Archives of Public Health
Background Experiential learning about food, nutrition and sustainability (FNS) at school promotes population health and environmental sustainability.
Jessica V. Kempler, Claire Margerison, Janandani Nanayakkara, Alison Booth   +3 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Comparing perceived and objectively measured changes in physical activity and sedentary time after a 12-week Internet-based intervention

, 2015
Purpose: Evidence suggests that physical inactivity and sedentary time (ST) are independent risk factors for poor health. While there have been many successful interventions targeting these lifestyle behaviours, few studies have examined the relationship
Rosenkranz, Richard R. (R15136), George, Emma S. (R17418), Guagliano, Justin M., Kolt, Gregory S. (R11602)   +3 more
core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

10,000 Steps Rockhampton: A Whole Community Approach to Increasing Levels of Physical Activity

, 2003
10,000 Steps Rockhampton is a multi-strategy health promotion program which aims to develop sustainable community-based strategies to increase physical activity.The central coordinating focus of the project is the use of pedometers to raise awareness of ...
Eakin, Elizabeth, Brown, Wendy, Schofield, Grant, Trost, Stewart G., Trost, Stewart, Mummery, Kerry, Abernethy, Peter   +6 more
core