Results 101 to 110 of about 12,919,610 (303)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

A randomised controlled trial and cost-effectiveness evaluation of 'booster' interventions to sustain increases in physical activity in middle-aged adults in deprived urban neighbourhoods [PDF]

, 2014
Background: More evidence is needed on the potential role of 'booster' interventions in the maintenance of increases in physical activity levels after a brief intervention in relatively sedentary populations.
Daniel Hind, Goyder, E, Breckon, Jeff D., Walters, Stephen John, Jeff Breckon, Crank, Helen, Dimairo, Munyaradzi, Kesterton, Sue, Emma Scott, Breckon, Jeff, Minton, Jonathan, Walters, S, Copeland, Robert, Robert Copeland, Humphreys, Liam, Rebecca Wood, Horspool, K, Peter Swaile, Hind, D. (Daniel), Wood, Rebecca, Dimairo, M, Goyder, Elizabeth, Collins, Karen, Liam Humphreys, Stephen J Walters, Scott, Emma, Kimberly Horspool, Karen Collins, Helen Crank, Minton, J, Nicolas Latimer, Everson-Hock, Emma, Hutchison, Andrew, Latimer, Nicolas, Sue Kesterton, Hind, Daniel, Hutchinson, A, Cooper, Cindy, Elizabeth Goyder, Read, Simon, Everson-Hock, E, Reade, Simon, Munyaradzi Dimairo, Jonathan Minton, Emma Everson-Hock, Cindy Cooper, Latimer, Nicholas, Hind, D, Horspool, Kimberly, Simon Read, Cooper, C, Andrew Hutchison, Walters, Stephen J, Swaile, Peter, Latimer, N   +54 more
core   +1 more source

Interventions to Promote Physical Activity by Older Adults [PDF]

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2001
Physical inactivity has been established to be an independent risk factor for a range of chronic diseases and conditions that threaten the health of the nation. However, only a minority of the population is currently meeting the recommended levels of regular physical activity, which have been linked with important health and quality-of-life benefits ...
openaire   +2 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

An intervention to promote Healthy Eating and Physical Activity in Lebanese School children: Health-E-PALS a pilot cluster randomised controlled trial [PDF]

, 2013
Aim and objectives: The purpose of this study was to develop, implement and evaluate the effectiveness of a multicomponent school-based intervention that focused on promoting healthy eating and physical activity with school children (aged 9 to 11 years ...
HABIB-MOURAD, CARLA
core  

Physical activity as an aid to smoking cessation during pregnancy: Two feasibility studies [PDF]

, 2008
Background: Pharmacotherapies for smoking cessation have not been adequately tested in pregnancy and women are reluctant to use them. Behavioural support alone has a modest effect on cessation rates; therefore, more effective interventions are needed ...
Marcus Bess, Michael Ussher, Lewis Beth, Coleman, T, Robert West, Bess Marcus, West, R, Ussher, M, Straus Lianne, Lewis, B, Lewis, Beth, Coleman Tim, Coleman, Tim, Straus, L, Aveyard Paul, West Robert, Aveyard, P, Beth Lewis, Marcus, B, West, Robert, Paul Aveyard, Isaac Manyonda, Manyonda, I, Tim Coleman, Manyonda, Isaac, Lianne Straus, Marcus, Bess, Ussher, Michael, Ussher Michael, Straus, Lianne, Manyonda Isaac, Aveyard, Paul   +31 more
core   +2 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

A web-based physical activity promotion intervention for inactive parent-child dyads: Protocol for a randomized controlled trial [PDF]

Background: Low levels of physical activity are associated with numerous adverse health outcomes, yet sedentary lifestyles are common among both children and adults.
Rhodes, Ryan, Hassandra, Mary, Ruiz, Montse C, Hamilton, Kyra, Hankonen, Nelli, Toivonen, Hanna-Mari, Kärkkäinen, Tommi, Chan, Derwin King, Aho, Reetta, Polet, Juho, Schneider, Jekaterina, Phipps, Daniel, Hagger, Martin, Kettunen, Eeva, Kykyri, Virpi Liisa, Green, Weldon Thomas, Kykyri, Virpi-Liisa, Knittle, Keegan, Toivonen, Hanna Mari, Laukkanen, Arto, Ruiz, Montse C., Lintunen, Taru, Sääkslahti, Arja, Biddle, Stuart, Aunola, Kaisa, Sääkslaht, Arja   +25 more
core   +1 more source

Do walking strategies to increase physical activity reduce reported sitting in workplaces: A randomized control trial [PDF]

, 2009
Background Interventions designed to increase workplace physical activity may not automatically reduce high volumes of sitting, a behaviour independently linked to chronic diseases such as obesity and type II diabetes.
Burton, Nicola W., Cooke, CB, Puig-Ribera, Anna, Burton, NW, Gilson, Nicolas D., Nicholas D Gilson, McKenna, J, Nicola W Burton, Gilson, N., Puig Ribera, Anna, Gilson Nicholas D, McKenna Jim, Wendy J Brown, Gilson, Nicholas D, Gilson, Nicholas D., Brown Wendy J, McKenna, J., Cooke Carlton B, Puig-Ribera, A, Cooke, Carlton B., Burton Nicola W, Brown, WJ, Brown, Wendy J., Brown, W., Burton, N., Puig-Ribera Anna, Gilson, ND, Anna Puig-Ribera, Puig-Ribera, A., Carlton B Cooke, Jim McKenna, McKenna, Jim   +31 more
core   +1 more source

Intracycle Velocity Variation During a Single-Sculling 2000 m Rowing Competition

Sensors
Rowing is a cyclic sport that consists of repetitive biomechanical actions, with performance being influenced by the balance between propulsive and resistive forces.
Joana Leão, Ricardo Cardoso, Jose Arturo Abraldes, Susana Soares, Beatriz B. Gomes, Ricardo J. Fernandes   +5 more
doaj   +1 more source