Results 91 to 100 of about 12,919,610 (303)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Effect of a school-based intervention to promote healthy lifestyles in 7–11 year old children. [PDF]

, 2009
Copyright 2009 Goreley et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/2.0/, which permits unrestricted use, distribution ...
Nevill, A, Mary E Nevill, John G Morris, Morris, John G., Morris John G, Gorely Trish, Nevill, Alan M., Stensel David J, Nevill, Mary E., Stensel, DJ, David J Stensel, Trish Gorely, Nevill Alan, Nevill Mary E, Stensel, David J., Alan Nevill, Morris, JG, Gorely, Trish, Nevill, ME, Gorely, T   +19 more
core   +1 more source

Addressing insufficient physical activity in children with obesity in a 4-month physical activity on prescription intervention: a single-group pre–post study

BMC Public Health
Background Childhood obesity is a complex disease and a growing global public health challenge. Physical activity on prescription (PAP) is an evidence-based method to increase physical activity (PA) in adults but has been sparsely studied in children ...
Jessica Törnqvist, Katarina Lauruschkus, Susanne Bernhardsson, Karin Melin, Li Karlsson, Daniel Arvidsson, Jonatan Fridolfsson, Christian Greven, Stefan Lundqvist   +8 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

A randomised controlled trial of physical activity promotion in primary care. [PDF]

Aim of study: To compare the effectiveness of two contrasting communication styles with a no-intervention control group on self reported physical activity at 12 months follow up. Study Design: 1-year randomised controlled trial.
Hillsdon, Melvyn
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Evaluation of a school-based physical activity intervention in Alexandra Township

, 2010
Objectives. Non-communicable diseases and limited participation in school physical education have become increasing concerns in South Africa. In response to these concerns, a school based physical activity intervention, Healthnutz, was implemented in ...
Draper, Catherine E., Grimsrud, Anna T., Lambert, Estelle V., Nemutandani, Simon, de Kock, Lauren, Kolbe-Alexander, Tracy, Rudolph, Michael   +6 more
core   +1 more source

Exploring the link between recreational substances and physical activity in children and adolescents: insights from the Health Behavior in School-Aged Children study (2013–2019)

BMC Public Health
Background Substance use and physical inactivity in youths could influence brain development, academic performance, and long-term physical and mental health outcomes.
Camila Miño, Rodrigo Yañéz-Sepúlveda, Héctor Gutiérrez-Espinoza, Jorge Olivares-Arancibia, María Rúa-Alonso, Joaquín Calatayud, Rubén López-Bueno, José Francisco López-Gil   +7 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Comparing perceived and objectively measured changes in physical activity and sedentary time after a 12-week Internet-based intervention

, 2015
Purpose: Evidence suggests that physical inactivity and sedentary time (ST) are independent risk factors for poor health. While there have been many successful interventions targeting these lifestyle behaviours, few studies have examined the relationship
Rosenkranz, Richard R. (R15136), George, Emma S. (R17418), Guagliano, Justin M., Kolt, Gregory S. (R11602)   +3 more
core