Results 71 to 80 of about 12,919,610 (303)

Integrating the promotion of physical activity within a smoking cessation programme: Findings from collaborative action research in UK Stop Smoking Services [PDF]

, 2010
Background: Within the framework of collaborative action research, the aim was to explore the feasibility of developing and embedding physical activity promotion as a smoking cessation aid within UK 6/7-week National Health Service (NHS) Stop Smoking ...
Everson-Hock, ES, Taylor Adrian H, Adrian H Taylor, Taylor, AH, Michael Ussher, Taylor, Adrian H, Taylor, Adrian H., Taylor, A.H., Everson-Hock, Emma S, Everson-Hock Emma S, Ussher, M, Ussher, M., Everson-Hock, E.S., Everson-Hock, Emma S., Ussher, Michael, Ussher Michael, Emma S Everson-Hock   +16 more
core   +2 more sources

The Effects of Strength and Conditioning in Physical Education on Athletic Motor Skill Competencies and Psychological Attributes of Secondary School Children: A Pilot Study

Sports, 2020
Leading global physical activity guidelines advocate that young children need to engage in activities that strengthen musculoskeletal tissues and improve movement skill competency.
Ben J. Pullen, Jon L. Oliver, Rhodri S. Lloyd, Camilla J. Knight   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Baseline White Matter Is Associated With Physical Fitness Change in Preclinical Alzheimer’s Disease

Frontiers in Aging Neuroscience, 2020
White matter (WM) microstructure is a sensitive marker to distinguish individuals at risk of Alzheimer’s disease. The association of objective physical fitness (PF) measures and WM microstructure has not been explored and mixed results reported with ...
Vijay K. Venkatraman, Christopher E. Steward, Christopher E. Steward, Kay L. Cox, Kathryn A. Ellis, Kathryn A. Ellis, Kathryn A. Ellis, Pramit M. Phal, Pramit M. Phal, Matthew J. Sharman, Victor L. Villemagne, Victor L. Villemagne, Michelle M. Y. Lai, Michelle M. Y. Lai, Michelle M. Y. Lai, Elizabeth V. Cyarto, David Ames, David Ames, David Ames, Cassandra Szoeke, Cassandra Szoeke, Cassandra Szoeke, Christopher C. Rowe, Christopher C. Rowe, Colin L. Masters, Nicola T. Lautenschlager, Nicola T. Lautenschlager, Patricia M. Desmond, Patricia M. Desmond   +28 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The Correlations Between Training Load Parameters and Physical Performance Adaptations in Team Sports: A Systematic Review and Meta-analysis

Sports Medicine - Open
Background Collating evidence on the relationship between training load and physical fitness adaptations in team sport players can help refine training plans. Objectives This systematic review and meta-analysis aimed to: (i) identify research designs and
Filipe Manuel Clemente, Aaron T. Scanlan, Rodrigo Ramirez-Campillo, Diogo Martinho, Rohit Kumar Thapa, Karim Chamari, Rui Miguel Silva, Jason Moran, Hugo Sarmento, Qi Xu, José Afonso   +10 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source