Results 51 to 60 of about 1,776,687 (293)

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Molecules in Bipolar Outflows

, 2012
Bipolar outflows constitute some of the best laboratories to study shock chemistry in the interstellar medium. A number of molecular species have their abundance enhanced by several orders of magnitude in the outflow gas, likely as a combined result of ...
Arce, Bachiller, Bachiller, Bachiller, Bisschop, Bjerkeli, Bontemps, Cernicharo, Codella, Davis, Elitzur, Faure, Flower, Gusdorf, Kristensen, Liseau, Mario Tafalla, Nisini, Nisini, Rafael Bachiller, Rodríguez-Fernández, Rosenthal, Santiago-García, Schöier, Tafalla, Tafalla, Tafalla   +26 more
core   +1 more source

PRACTICAL PHYSICAL CHEMISTRY. [PDF]

Journal of the American Chemical Society, 1907
n ...
openaire   +2 more sources

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

STUDIES IN THE PHYSICAL CHEMISTRY OF THE PROTEINS [PDF]

, 1924
Edwin J. Cohn, Ruth Berggren
openalex   +3 more sources

Reactive molecular dynamics simulations of organometallic compound W(CO)6 fragmentation

, 2019
Irradiation- and collision-induced fragmentation studies provide information about geometry, electronic properties and interactions between structural units of various molecular systems. Such knowledge brings insights into irradiation-driven chemistry of
de Vera, Pablo, Solov'yov, Andrey V., Sushko, Gennady, Verkhovtsev, Alexey   +3 more
core   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Insights into the Carbon chemistry of Mon R2

, 2005
Aiming to learn about the chemistry of the dense PDR around the ultracompact (UC) HII region in Mon R2, we have observed a series of mm-wavelength transitions of C3H2 and C2H. In addition, we have traced the distribution of other molecules, such as H13CO+
A. Fuente, Chandra S., Fuente A., Garcia-Burillo S., Henning T., J. R. Rizzo, Le Bourlot J., Massi M., Rodriguez-Franco A., S. Garcia‐Burillo, Truong-Bach, Walmsley C. M.   +11 more
core   +3 more sources

PROBLEMS OF PHYSICAL CHEMISTRY. [PDF]

Journal of the American Chemical Society, 1892
n ...
openaire   +3 more sources

Tumor‐agnostic detection of circulating tumor DNA in patients with advanced pancreatic cancer using targeted DNA methylation sequencing and cell‐free DNA fragmentomics

Molecular Oncology, EarlyView.
We evaluated circulating tumor DNA (ctDNA) detection in advanced pancreatic cancer using DNA methylation, cell‐free DNA fragment lengths, and 5′ end motifs. Machine learning models were trained to estimate ctDNA levels from each feature and their combination.
Morten Lapin, Kjersti Tjensvoll, Karin Hestnes Edland, Satu Oltedal, Herish Garresori, Bjørnar Gilje, Saga Ekedal, Trygve Eftestøl, Jan Terje Kvaløy, Filip Janku, Oddmund Nordgård   +10 more
wiley   +1 more source