Results 51 to 60 of about 64,625 (272)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Evacuation in the Social Force Model is not stationary

, 2011
An evacuation process is simulated within the Social Force Model. Thousand pedestrians are leaving a room by one exit. We investigate the stationarity of the distribution of time lags between instants when two successive pedestrians cross the exit.
Gawroński, P., Kantelhardt, J. W., Kułakowski, K., Kämpf, M.   +3 more
core   +1 more source

Methodology for the Diagnosis of Hydromechanical Actuation Loops in Aircraft Engines [PDF]

, 2012
This document provides a method for on-board monitoring and on-ground diagnosis of a hydromechanical actuation loop such as those found in aircraft engines. First, a complete system analysis is performed to understand its behaviour and determine the main
LAMOUREUX, Benjamin, MASSÉ, Jean-Rémi, MECHBAL, Nazih   +2 more
core   +5 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

The Influence of Block Games and Coconut Shell Clogs on Students’ Physical Fitness in Learning Physical Education, Sports, and Health

Journal of Social Work and Science Education, 2023
The purpose of this study was the effect of the game hadang and Tempurung Bakiak on the physical fitness of students in learning physical education, sports, and health at SMP Negeri 27 Palembang. This research was conducted at SMP Negeri 27 Palembang which is located on Jl. Rejung No. 198, Sako Baru, Kec. Sako, Palembang City, South Sumatra 30961.
Nazom Nurhawi AR, Meilia Rosani, M Taheri Akhbar   +2 more
openaire   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Precursory arch-like structures explain the clogging probability in a granular hopper flow

Communications Physics
The clogging phenomenon finds extensive application in both industrial processes and daily life events. While this broad spectrum of application motivated extensive research to identify the general factors underlying the clogging mechanism, it results in
Shuyang Zhang, Zhikun Zeng, Houfei Yuan, Zhifeng Li, Yujie Wang   +4 more
doaj   +1 more source

Modelling the Influence of the Tube Support Plate on the Eddy Current Testing of the Steam Generator: Numerical Tools and Experimental Validation

e-Journal of Nondestructive Testing, 2023
Eddy current testing (ECT) of Steam Generator (SG) tubes is part of the maintenance program of Nuclear Power Plants. Tube Support Plates (TSP) are usually only considered as extraneous signals for tube inspection. However, for long-term operation of SGs,
Audrey Vigneron, Edouard Demaldent, Jean-Marc Decitre, Thierry Sollier   +3 more
doaj   +1 more source

Granular discharge and clogging for tilted hoppers

, 2009
We measure the flux of spherical glass beads through a hole as a systematic function of both tilt angle and hole diameter, for two different size beads.
C. Mankoc, C.E. Davies, C.R. Wassgren, C.S. Chang, C.S. O’Hern, C.T. Veje, Douglas J. Durian, F.C. Franklin, F.J. Muzzio, G.W. Baxter, H. Pacheco-Martinez, H.M. Jaeger, Hannah G. Sheldon, I. Zuriguel, I. Zuriguel, J. Choi, J. Duran, J.F. Wambaugh, K. Chen, K. Schick, M.L. Hunt, P. Evesque, R.M. Nedderman, R.M. Nedderman, S. Saraf, S.S. Manna, T. Raafat, U. Tuzun, W.A. Beverloo, X.l. Wu   +29 more
core   +1 more source