Results 161 to 170 of about 9,130,451 (295)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Exploring body composition and physical condition profiles in relation to playing time in professional soccer: a principal components analysis and Gradient Boosting approach. [PDF]

Front Physiol
Ulloa-Díaz D, Fábrica-Barrios G, Jorquera-Aguilera C, Guede-Rojas F, Pérez-Contreras J, Lozano-Jarque D, Carvajal-Parodi C, Romero-Vera L.   +7 more
europepmc   +1 more source

Evaluating effects of the structural reform of outpatient psychotherapy for patients with mental disorders in Germany: comparing patients with and without comorbid chronic physical condition - rationale and study protocol of the ES-RiP project. [PDF]

BMJ Open, 2022
Kampling H, Kruse J, Friederich HC, Heuft G, Christoffer A, Grobe TG, Marschall U, Szecsenyi J, Wild B, Hartmann M, ES-RiP-Consortium Study Group.   +10 more
europepmc   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

The Role of Nutrition in Maintaining the Health and Physical Condition of Sports Volunteers. [PDF]

Nutrients
Rozmiarek M.
europepmc   +1 more source

Relationship of Physical Activity to Self-Care Agency and Physical Condition Among Older Adults in a Rural Area. [PDF]

Yonago Acta Med, 2021
Yoshimura J, Tanimura C, Matsumoto H, Tokushima Y, Inoue K, Park D, Hagino H.   +6 more
europepmc   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Patient physical condition and functional sequelae following hospitalization with COVID-19: A cross-sectional observational study. [PDF]

Medicine (Baltimore)
Ángel García D, Calvo Muñoz I, Martínez Nicolás I, Salmeri B.   +3 more
europepmc   +1 more source

CONDITIONS OF PHYSICAL ACTIVITY

Rehabilitation and Recreation, 2023
D. Czarnecki, D. W. Skalski, D. Jabłońska-Mazurek, M. Graczyk, B. Kindzer, T. Gamma   +5 more
openaire   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source