Results 51 to 60 of about 7,695,929 (272)

The time of the earthlings

Techne, 2020
«Sun does not always shine and the wind does not always blow» (Rifkin, 2011). Looks like we have a problem. Our problem is time. It is an ancient human problem to want to predict.
Teodoro Georgiadis
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

New epistemological foundations for cultural psychology: from an atomistic to a self-organizing view of living systems

Annali dell'Istituto Superiore di Sanità, 2014
An epistemological foundation for cultural psychology is essential to neuro- and behavioural sciences for the challenge psychological sciences must currently face: searching for an explanation of how a brain can become a mind and how individuals assign a
Adele De Pascale
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Impact of enriched environment on motor performance and learning in mice

Scientific Reports
Neuroscience heavily relies on animal welfare in laboratory rodents as it can significantly affect brain development, cognitive function and memory formation.
S. Dijkhuizen, L. M. C. Van Ginneken, A. H. C. IJpelaar, S. K. E. Koekkoek, C. I. De Zeeuw, H. J. Boele   +5 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Repercussões cardíacas após infarto do miocárdio em ratas submetidas previamente a exercício físico Cardiac implications after myocardial infarction in rats previously undergoing physical exercise

Arquivos Brasileiros de Cardiologia, 2013
FUNDAMENTO: Poucos estudos analisaram os efeitos cardíacos do exercício físico prévio à oclusão coronariana. OBJETIVO: Avaliar, em ratas submetidas a exercício físico, as repercussões do infarto do miocárdio.
Eduardo Carvalho de Arruda Veiga, Leslie Andrews Portes, Danilo Sales Bocalini, Ednei Luiz Antonio, Alexandra Alberta dos Santos, Marília Higuchi Santos, Flavio André Silva, Paulo José Ferreira Tucci   +7 more
doaj  

Development of an International Qualification Framework for the strength and conditioning profession: International Universities Strength and Conditioning Association Position Statement.

In the profession of strength and conditioning (S&C), there is a need for a standardised, comprehensive framework that can allow for the alignment of international certifications, qualifications, and standards.
Bird, Stephen P., Langford, Andrew, Flannagan, Aden, Marchetti, Paulo H.   +3 more
core   +1 more source