Results 71 to 80 of about 116,030 (268)

Physical Conditioning & Fatigue (33)

, 1969
Physical Conditioning & Fatigue: Exercise record for J ...

core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Physical Conditioning & Fatigue (26)

, 1970
Physical Conditioning & Fatigue: Exercise record for J ...

core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Effects of exercise in people with multiple sclerosis: a systematic review and meta-analysis

Frontiers in Public Health
BackgroundA growing body of studies have examined the effect of exercise in people with multiple sclerosis (MS), while findings of available studies were conflicting. This meta-analysis aimed to explore the effects of exercise on balance, walking ability,
Liwen Du, Liwen Du, Haoyu Xi, Haoyu Xi, Shiyan Zhang, Yilun Zhou, Xifeng Tao, Yuanyuan Lv, Xiao Hou, Xiao Hou, Laikang Yu, Laikang Yu   +11 more
doaj   +1 more source

Physical Conditioning, Obesity and Fibromyalgia: Causal Relationship or Confounding? [PDF]

Princ Pract Clin Res, 2023
Costa V, Gianlorenço AC, Daibes M, Queiroz F, Lacerda G, Martinez-Magallanes D, Camargo L, Alves LG, Andrade MF, Dodurgali MR, Pacheco-Barrios K, Fregni F.   +11 more
europepmc   +1 more source

Physical Conditioning & Fatigue (31)

, 1970
Physical Conditioning & Fatigue: Exercise record for J ...

core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Physical Conditioning & Fatigue (16)

, 1970
This image reflects a view of Physical Conditioning & Fatigue treadmill study results from Dr.

core  

Development of an International Qualification Framework for the strength and conditioning profession: International Universities Strength and Conditioning Association Position Statement.

In the profession of strength and conditioning (S&C), there is a need for a standardised, comprehensive framework that can allow for the alignment of international certifications, qualifications, and standards.
Bird, Stephen P., Langford, Andrew, Flannagan, Aden, Marchetti, Paulo H.   +3 more
core   +1 more source