Results 81 to 90 of about 116,030 (268)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Effects of nutritional supplementation combined with exercise on BMI and lipid profiles in individuals with overweight or obesity: a systematic review and meta-analysis

Frontiers in Nutrition
BackgroundThis study systematically evaluated the effects of nutritional supplementation combined with exercise on BMI and lipid profiles in individuals with overweight or obesity.MethodsA systematic search was conducted in PubMed, Embase, Web of Science,
Hongling Cheng, Chengyu Zhou, Shiwei Song, Bo Wang, Diandong Lang, Peng Sun   +5 more
doaj   +1 more source

Physical Conditioning & Fatigue (37)

, 1973
Physical Conditioning & Fatigue: an exercise record graph of Preflight, Post flight, and Post Shower results for Subject No ...

core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Physical Conditioning & Fatigue (41)

, 1973
Physical Conditioning & Fatigue: Exercise record for Subject No.

core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Efficacy and moderators of isometric resistance training (IRT) on resting blood pressure among patients with pre- to established hypertension: a multilevel meta-review and regression analysis

BMC Sports Science, Medicine and Rehabilitation
Objective This study aims to evaluate the efficacy of isometric resistance training (IRT) in lowering blood pressure through meta-analyses, specifically systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP), in ...
Chengyu Zhou, Sijia Li, Zengyu Zhang, Jiamin Chen, Jian Song, Yongmin Xie, Zhuolin Tang, Aiguo Zhou   +7 more
doaj   +1 more source

Comparative Study of the Sprint Start Biomechanics of Men’s 100 m Athletes of Different Levels

Applied Sciences
Background: This study sought to investigate the kinematic and kinetic differences in sprint start between high-level and medium-level sprinters. Methods: Twenty male sprinters were dichotomized according to their personal 100 m performance.
Zhao Li, Yan Peng, Qing Li
doaj   +1 more source

Propuesta de intervención educativa para la enseñanza del aparato locomotor en el Grado de Técnico Superior en Acondicionamiento Físico [PDF]

Ikastorratza.e-Revista de Didáctica
This paper presents an innovative intervention proposal to teach the unit "Biomechanical: structures implicated in movement" in the Higher Technician Grade in Physical Conditioning Certificate. The main goal of this proposal is to provide students with a
Carolina Ansó López, María Casas Jericó   +1 more
doaj   +1 more source

Physical Conditioning Strategies for the Prevention of Concussion in Sport: a Scoping Review. [PDF]

Sports Med Open, 2021
Garnett D, Patricios J, Cobbing S.
europepmc   +1 more source