Results 81 to 90 of about 9,432,260 (352)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The use of running and jumping exercises in special motor training of young forwards 13–14 years old

Слобожанський науково-спортивний вісник, 2020
Purpose: to determine the effect of using complexes of various athletics running and jumping exercises on the indicators of the quantity and quality of technical and tactical motor actions of young forwards-football players 13–14 years old.
Yaroslav Kraynik, Vyacheslav Mulyk, Volodimir Perevoznik , Svyatoslav Koval   +3 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Use of special exercises for the development of motor qualities and the formation of technical and tactical actions of defenders 13–14 years in the preparatory period

Слобожанський науково-спортивний вісник, 2019
Purpose: to develop the content of training programs for the extreme and central defenders using special exercises in accordance with the game role and determine the effectiveness of their use in young football players 13–14 years old. Material & Methods:
Yaroslav Kraynik, Vyacheslav Mulik, Daria Okun , Svyatoslav Koval   +3 more
doaj   +1 more source

Physical condition of pupils of pre-school educational establishments of different types

Pedagogy of Physical Culture and Sports, 2020
The purpose of the study is to determine the physical condition of the pupils of pre-school educational establishments of various types for improving the quality of the educational process of physical education. Material and methods .
N.V. Moskalenko, V.G. Savchenko, A.V. Polyakova, O.S. Mikitchik, O.O. Mitova, V.V. Griukova, A.V. Mytsak   +6 more
doaj   +1 more source

The Brain Worker [PDF]

, 1899
"One is committing a sin against himself if he does not take proper care of his body—if he does not develop those powers which lie dormant within, ready to spring forth into life at the touch of the "magic hand" of the exuberant health obtained through ...
Smithson, J. Walter
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Monitoring student performance using computer technology

Слобожанський науково-спортивний вісник, 2019
Purpose: to develop a computer program for students of the department of martial arts of KSAPC, which allows you to monitor and account for their knowledge in the discipline "Theory and methods of the chosen sport" and "Varieties of wrestling". Material &
Vyacheslav Romanenko, Yura Tropin, Natalya Boychenko , Valeriy Goloha   +3 more
doaj   +1 more source

Health and wellbeing: a policy context for physical education in Scotland [PDF]

, 2012
The positioning of physical education in the school curriculum continues to reflect external discourses circulating in political and social milieu. As increasing austerity measures influence and restrict educational priorities, we consider that there is ...
Gray, Shirley; id_orcid, Horrell, Andrew, Andrew Horrell, Horrell, Andrew Brian, Sproule, John, John Sproule, Shirley Gray, Thorburn, Malcolm   +7 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source