Results 61 to 70 of about 283,703 (294)

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Is the impact of social distancing on coronavirus growth rates effective across different settings? A non-parametric and local regression approach to test and compare the‘doubling rate [PDF]

open access: yes, 2020
Epidemiologists use mathematical models to predict epidemic trends, and these results are inherently uncertain when parameters are unknown or changing.
Lancastle, Neil
core  

TRANSFORMATION OF THE PRIVATE/PUBLIC DIVIDE IN THE TIMES OF COVID-19: HOW ECONOMYDRIVEN POLICIES ARE RESHAPING THE CONCEPT OF SOCIAL/PHYSICAL DISTANCING IN SERBIA

open access: yesKöz-gazdaság, 2021
The evolution of social/physical distancing narratives throughout the COVID19 pandemic has left the concept itself ambiguous and vague while cutting through the borderlines between private and public.
Ivana Stepanović
doaj  

Connection, constraint, and coping: A qualitative study of experiences of loneliness during the COVID-19 lockdown in the UK.

open access: yesPLoS ONE, 2021
The COVID-19 pandemic has necessitated physical distancing which is expected to continue in some form for the foreseeable future. Physical distancing policies have increased reliance on digital forms of social connection and there are widespread concerns
Phoebe E McKenna-Plumley   +3 more
doaj   +1 more source

Digital Orthopaedics: A Glimpse Into the Future in the Midst of a Pandemic. [PDF]

open access: yes, 2020
BackgroundThe response to COVID-19 catalyzed the adoption and integration of digital health tools into the health care delivery model for musculoskeletal patients. The change, suspension, or relaxation of Medicare and federal guidelines enabled the rapid
Ast, Michael P   +9 more
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Accessibility of ‘essential’ alcohol in the time of COVID-19: casting light on the blind spots of licensing? [PDF]

open access: yes, 2020
Among the Australian and UK governments’ responses to the COVID-19 pandemic has been the designation of outlets selling alcohol for off-premise consumption as ‘essential’ services, allowing them to remain open while pubs, hotels and restaurants have ...
Claire, Wilkinson, Reynolds, Joanna
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Exercise and COVID‐19: reasons individuals sought coaching support to assist them to increase physical activity during COVID‐19

open access: yesAustralian and New Zealand Journal of Public Health, 2021
Objective: This paper explores the experiences of individuals who reported substantially decreasing physical activity (PA) as a result of COVID‐19 and sought coaching support to increase PA.
Stephen Barrett   +4 more
doaj   +1 more source

Networked SIS Epidemics with Awareness

open access: yes, 2016
We study an SIS epidemic process over a static contact network where the nodes have partial information about the epidemic state. They react by limiting their interactions with their neighbors when they believe the epidemic is currently prevalent. A node'
Eksin, Ceyhun   +3 more
core   +1 more source

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