Results 61 to 70 of about 4,640,956 (291)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Exercise ameliorates muscular excessive mitochondrial fission, insulin resistance and inflammation in diabetic rats via irisin/AMPK activation

Scientific Reports
This study aimed to investigate the effects of exercise on excessive mitochondrial fission, insulin resistance, and inflammation in the muscles of diabetic rats.
Junjie Lin, Xin Zhang, Yu Sun, Haocheng Xu, Nan Li, Yuanxin Wang, Xin Tian, Chen Zhao, Bin Wang, Baishu Zhu, Renqing Zhao   +10 more
doaj   +1 more source

Characteristics of resting state functional connectivity of motor cortex of high fitness level college students: Experimental evidence from functional near infrared spectroscopy (fNIRS)

Brain and Behavior, 2023
Objective This study inspects difference of resting state functional connectivity (RSFC) of motor cortex between athletes and ordinary college students and the test‐retest reliability of RSFC.
Wenyi Li, Qi Zhang, Rui Yang, Bin Liu, Gonghe Chen, Bingyang Wang, Taiyu Xu, Jun Chen, Xuxue Zhou, Shilin Wen   +9 more
doaj   +1 more source

Evaluative criteria for elementary school physical education. [PDF]

, 1957
Thesis (Ed.M.)--Boston ...
Bergstrom, Merrill Stanley
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Water Physical Exercise Program (WPEP) Using High-Intensity Interval Training in Individuals With Parkinson’s Disease: A Clinical Trial Protocol

Parkinson's Disease
Trial Registration: Brazilian Register of Clinical Trials: RBR ...
Luís Henrique Paladini, Giovanna Cristina Leveck, Tainá Christinelli, Juliana Siega, André Eduardo Falcoski Doliny, Paulo Cesar Barauce Bento, Vera Lúcia Israel   +6 more
doaj   +1 more source

Teaching Python with team‐based learning: using cloud‐based notebooks for interactive coding education

FEBS Open Bio, EarlyView.
This study presents a novel approach to teaching Python and bioinformatics using team‐based learning and cloud‐hosted notebooks. By integrating interactive coding into biomedical education, the method improves accessibility, student engagement, and confidence—especially for those without a computing background.
Nuno S. Osório, Leonardo D. Garma
wiley   +1 more source

Effects of mini-basketball training program on social communication impairments and regional homogeneity of brain functions in preschool children with autism spectrum disorder

BMC Sports Science, Medicine and Rehabilitation
Background Social communication impairments (SCI) is a core symptom of autism spectrum disorder (ASD) and is marked by challenges in social interaction.
Yang Yang, Dandan Chen, Kelong Cai, Lina Zhu, Yifan Shi, Xiaoxiao Dong, Zhiyuan Sun, Zhiyuan Qiao, Yahui Yang, Weike Zhang, Haiyong Mao, Aiguo Chen   +11 more
doaj   +1 more source

Estimation of injury costs: financial damage of English Premier League teams’ underachievement due to injuries

BMJ Open Sport & Exercise Medicine, 2020
Background In individual sports, the effect that injuries have on an athlete’s performance, success and financial profit is implicit. In contrast, the effect of a single player’s injury or one player’s absence in team sports is much more difficult to ...
Eyal Eliakim, Elia Morgulev, Ronnie Lidor, Yoav Meckel   +3 more
doaj   +1 more source

Cis‐unsaturated sphingolipids support growth of sphingoid base‐deficient yeast but impair plasma membrane integrity

FEBS Open Bio, EarlyView.
Sphingoid base structures, the sphingolipid backbones, vary among species. We established yeast cells in which the native sphingoid base was replaced with plant‐type bases containing cis or trans double bonds. This is, to our knowledge, the first eukaryotic model mostly composed of sphingolipids containing cis‐unsaturated sphingoid base, providing a ...
Takashi Higuchi, Saki Sugihara, Yohei Ishibashi, Kono Yushi, Hazuki Yamauchi, Motohiro Tani   +5 more
wiley   +1 more source