Results 91 to 100 of about 370,479 (294)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Effects of speed, heart rate, lactate and uric acid on the performance of Arabian horses during a 120-Km endurance race [PDF]

, 2012
Speed, heart rate, lactate and uric acid alterations led to reduced performance and hamper the health status of endurance horses. The aim of this study was to investigate on the effects of speed, heart rate, lactate and uric acid on the performance of ...
Abdullah, Rasedee, Adamu, Lawan, Ahmad, Bashir, Mohd Adzahan, Noraniza   +3 more
core  

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Comparative Characteristics of the Physical Training of Women between 30 and 49 Years of Age Based on Indicators of Physical Training Depending on the Body Weight Fat Component Content

Фізичне виховання, спорт і культура здоров’я у сучасному суспільстві, 2017
The current relevance of the research. The paper is devoted to the research of fat body content influence on the parameters of physical state at 30-years women. It was determined that increasing of fat body content at 30–49 years women negatively affects
Svitlana Salnikova
doaj   +1 more source

New horizons for the methodology and physiology of training periodization: Block Periodization: New horizon or a false dawn? [PDF]

, 2010
It would appear premature to herald block periodization as a ‘new horizon’ in training planning, partly because of a fundamental lack of supporting evidence and clearly delineated rationale, and partly because contradictory evidence exists questioning ...
Balabinis, Beavan, Beavan, Bondarchuk, Bouchard, Brown, Brown, Davis, Dudley, Foster, Hennessy, Hickson, Hickson, Hickson, Hoff, Hoff, Hunter, Issurin, John Kiely, Kudielka, Matveyev, McCarthy, Mikkola, Mikkola, Millet, Nelson, Paavolainen, Rhea, Shaw, Skinner, Støren, Van Regenmortel, Verkhoshansky, Yamamoto   +33 more
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

The Correlation of Body Composition and Fitness Level of Students in Medical Faculty Unwar

WMJ (Warmadewa Medical Journal), 2019
Medical students beside they are as a member of the medical rescuer, the team is also to have good physical fitness due to consider that Indonesia involves a disaster drawn area.
Wayan Rusni , Komang Trisna Sumadewi , Tanjung Subrata   +2 more
doaj   +1 more source

Associations between anthropometric characteristics and physical performance in male law enforcement officers: A retrospective cohort study [PDF]

, 2016
BACKGROUND: Police officers are often required to undertake physically demanding tasks, like lifting, dragging and pursuing a suspect. Therefore, physical performance is a key requirement. METHODS: Retrospective data for 76 male police officers (mean age 
Dawes, James Jay, Orr, Robin Marc, Pope, Rodney, Siekaniec, Claire Louise, Vanderwoude, Andrea Annie   +4 more
core   +2 more sources