Results 71 to 80 of about 119,299 (308)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Hypertrophic cardiomyopathy and ultra-endurance running - two incompatible entities? [PDF]

, 2011
Regular and prolonged exercise is associated with increased left ventricular wall thickness that can overlap with hypertrophic cardiomyopathy (HCM). Differentiating physiological from pathological hypertrophy has important implications, since HCM is the ...
Sanjay K Prasad, Papadakis, M, Sharma Sanjay, Prasad, Sanjay K., Chandra, N, Prasad, SK, O'Hanlon, Rory, O'Hanlon Rory, Papadakis, Michael, O'Hanlon, R, Chandra, Navin, Prasad Sanjay K, Michael Papadakis, Sharma, Sanjay, Chandra Navin, Papadakis Michael, Rory O'Hanlon, Wilson, MG, Wilson, Mathew G., Wilson Mathew G, Sanjay Sharma, Sharma, S, Mathew G Wilson, Navin Chandra   +23 more
core   +1 more source

Physical efficiency of girls of 9-10 years in the process of physical training aimed at developing endurance [PDF]

Pedagogìka, Psihologìâ ta Mediko-bìologìčnì Problemi Fìzičnogo Vihovannâ ì Sportu, 2012
Essence of specific of evaluation of physical capacity opens up in physical education of girls. In researches 45 girls took part in age 9-10 years.
Samokih I.I.
doaj  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

National physical education curriculum: motor and cardiovascular health related fitness in Greek adolescents. [PDF]

, 2007
Background: State school physical education (PE) programmes are common throughout Greece. However, it is not known if the main objectives of the Greek PE curriculum are achieved.
Bouziotas, Constantin, Koutedakis, Yiannis   +1 more
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Clinicians' and patients' assessment of activity overuse and underuse and its relation to physical capacity [PDF]

, 2012
To explore clinicians' and patients' (self)-assessment of activity overuse and underuse, and its relationship with physical capacity in patients with chronic musculoskeletal pain (CMP). Study design was cross-sectional.
de Jong, A.B., Preuper, H.R.S., Reneman, M.F., Reneman, M.F.; id_orcid   +3 more
core   +1 more source

THE INFLUENCE OF DYNAMIC AND STATIC PHYSICAL EXERCISES ON THE PARAMETERS OF INTRACARDIAC HEMODYNAMICS AND PHYSICAL ENDURANCE IN HIGHER-LEVEL SPORTSMEN

Кардиоваскулярная терапия и профилактика, 2015
Aim. To assess the influence of dynamic and static exercises on the parameters of intracardiac hemodynamics and physical endurance in higher-level sportsmen.Material and methods. Totally, 136 sportsmen studied all males.
N. P. Garganeeva, I. F. Taminova, L. I. Tyukalova, I. N. Vorozhtsova, I. L. Bukhovets, E. N. Pashkova   +5 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source