Results 91 to 100 of about 373,963 (311)

Identifying characteristics of frailty in female mice using a phenotype assessment tool [PDF]

, 2019
Preclinical studies are important in identifying the underlying mechanisms contributing to frailty. Frailty studies have mainly focused on male rodents with little directed at female rodents.
Baumann, Cory W., Kwak, Dongmin, Thompson, LaDora V.   +2 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Bioavailability of orange juice (poly)phenols: the impact of short-term cessation of training by male endurance athletes [PDF]

, 2017
Background: Physical exercise has been reported to increase the bioavailability of citrus flavanones. Objective: To investigate the bioavailability of orange juice (OJ) (poly)phenols in endurance-trained men before and after cessation of training for 7 ...
Crozier, Alan, Garcia, Ada L., Ludwig, Iziar A., Malkova, Dalia, Moreno-Rojas, Manuel, Natase, Ana-Maria, Pereira-Caro, Gema, Polyviou, Thelma   +7 more
core   +2 more sources

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

Biochemical aspects of KB-28 compound on physically loaded study subjects

Current Issues in Pharmacy and Medical Sciences, 2019
In previous studies of actoprotective activity of 5-R-thio-tetrazolo[1,5]quinazoline derivatives in normal and complicated experimental conditions, sodium 2-(tetrazolo [1,5-c]quinazoline-5-ylthio)acetate (KB-28) was found to be the leader of the ...
Toziuk Olena, Krasna Olga, Kryvoviaz Olena, Rodinkova Victoria, Melnyk Andrii, Ivko Tanya, Voronkina Alona, Hutsol Viktoriia   +7 more
doaj   +1 more source

The potential role of genetic markers in talent identification and athlete assessment in elite sport [PDF]

, 2018
In elite sporting codes, the identification and promotion of future athletes into specialized talent pathways is heavily reliant upon objective physical, technical, and tactical characteristics, in addition to subjective coach assessments.
Anderton, Ryan S, Hart, Nicolas H, Jacob, Ysabel, Spiteri, Tania   +3 more
core   +2 more sources

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Effect of age and performance on physical, hematological and biochemica parameters in endurance horses. [PDF]

, 2013
Endurance horses are subjected to heightened stress even after several conditioning protocols. Hence, the goal of this study was to examine the effect of age and performance on the hematology, biochemistry, and physical parameters after an endurance race.
Abdullah, Rasedee, Adamu, Lawan, Fateh Mohamed, Bashir Ahmad, Mohd Adzahan, Noranizan   +3 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A Combined Exercise Program in Sedentary Older Adults: A Randomized Control Trial [PDF]

Journal of Rehabilitation Sciences and Research
Background: This study investigated the effectiveness and durability of a combined exercise program on strength, endurance, speed, agility, flexibility, and quality of life in sedentary older adults.Methods: In this randomized controlled trial, 27 older ...
Behnoosh Aminikhah, hamed babagoltabar-samakoush, Behnam Gholami-Borujeni   +2 more
doaj   +1 more source