Results 91 to 100 of about 119,299 (308)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

A study of the relationship between the general physical fitness of adolescents aged 15 – 19 years and their parents [PDF]

, 2008
The purpose of this study was to determine the degree of familial resemblance in general physical fitness between adolescents and their parents. Data was gathered from a sample of adolescent-parent pairs.
Law, Christopher J.
core  

Actoprotective action of sodium 2-(tetrazol[1,5-c]quinazolin-5-ylthio)acetate in acute hemic hypoxia

Zaporožskij Medicinskij Žurnal, 2017
Enough energy and good oxygen supply of the organism is necessary to maintain high performance level. Hypoxic process develops rapidly during intense physical exertion. This prevents the execution of tasks, and under certain circumstances endangers human
O. Yu. Toziuk
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Upregulation of cardioprotective SUR2A by sub-hypoxic drop in oxygen [PDF]

, 2014
The effects of hypoxia on gene expression have been vigorously studied, but possible effects of small changes in oxygen tension have never been addressed.
Sukhodub, Andriy, Mohammed Abdul, Khaja Shameem, Du, Qingyou, Jovanovic, Aleksandar, Khaja Shameem Mohammed Abdul, Sofija Jovanović, Jovanovic, Sofija, Aleksandar Jovanović, Andriy Sukhodub, Qingyou Du   +9 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Effects of combined strength and endurance training on body composition and physical fitness in soldiers during a 6-month crisis management operation

, 2021
The aim of this thesis was to study a) physical activity, workload and stress in soldiers, b) effects of combined strength and endurance training on body composition and physical performance, and c) training-induced changes in endurance performance ...
Pihlainen, Kai
core   +1 more source

A Combined Exercise Program in Sedentary Older Adults: A Randomized Control Trial [PDF]

Journal of Rehabilitation Sciences and Research
Background: This study investigated the effectiveness and durability of a combined exercise program on strength, endurance, speed, agility, flexibility, and quality of life in sedentary older adults.Methods: In this randomized controlled trial, 27 older ...
Behnoosh Aminikhah, hamed babagoltabar-samakoush, Behnam Gholami-Borujeni   +2 more
doaj   +1 more source