Results 61 to 70 of about 119,299 (308)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Enhancing endurance performance with combined imagined and actual physical practice

, 2023
Endurance sports require the sustained maintenance of high effort until the point of task failure. Psychological factors, particularly the perception of effort, exert considerable influence in determining task failure.
Mathieu Gruet, Robin Souron, Nathan Grosboillot, Aymeric Guillot, Mathilde F Bertrand, Thomas Lapole, Benjamin Pageaux, Guillaume Y. Millet   +7 more
core   +1 more source

Effect of Core Stability Training on the Endurance and Strength of Core in Basketball Players with Trunk Dysfunction

Journal of Rehabilitation Sciences and Research, 2020
Background: Core stability is predominantly provided by the dynamic function of musculature. Although poor core stability ultimately leads to injury, a proper training can reduce injury.
Ebrahim Mohammad Ali Nasab Firouzjah, Hassan Daneshmandi, Ali Asghar Norasteh   +2 more
doaj   +1 more source

Altitude Training and its Influence on Physical Endurance in Swimmers

Journal of Human Kinetics, 2011
Altitude Training and its Influence on Physical Endurance in Swimmers It is possible to plan an altitude training (AT) period in such a way that the enhanced physical endurance obtained as a result of adaptation to hypoxia will appear and can be used to improve performance in competition.
Strzała, Marek, Ostrowski, Andrzej, Szyguła, Zbigniew   +2 more
openaire   +2 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Comparative Characteristics of the Physical Training of Women between 30 and 49 Years of Age Based on Indicators of Physical Training Depending on the Body Weight Fat Component Content

Фізичне виховання, спорт і культура здоров’я у сучасному суспільстві, 2017
The current relevance of the research. The paper is devoted to the research of fat body content influence on the parameters of physical state at 30-years women. It was determined that increasing of fat body content at 30–49 years women negatively affects
Svitlana Salnikova
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Bone mineral density and bone turnover in male master track and field athletes aged 40-64

, 2010
We evaluated areal bone mineral density (aBMD), bone mineral content (BMC), and markers of bone turnover in male competitive masters athletes representing different training profile in the past and at present, aged 40–64 (14 endurance runners, and 12 ...
Rittweger, Jörn, Straburzyńska-Migaj, Ewa, Nowak, Alicja, Kusy, Krzysztof, Straburzynksa-Lupa, Anna, Nowak, Alicija, Zielinski, Jacek, Felsenberg, Dieter, Straburzynksa-Migaj, Ewa, Straburzyńska-Lupa, Anna, Pilaczyńska-Szcześniak, Lucja, Pilaczynska-Sczesniak, Lucja, Karolkiewicz, Joanna   +12 more
core   +1 more source

The Correlation of Body Composition and Fitness Level of Students in Medical Faculty Unwar

WMJ (Warmadewa Medical Journal), 2019
Medical students beside they are as a member of the medical rescuer, the team is also to have good physical fitness due to consider that Indonesia involves a disaster drawn area.
Wayan Rusni , Komang Trisna Sumadewi , Tanjung Subrata   +2 more
doaj   +1 more source