Results 91 to 100 of about 4,724,720 (298)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
PHYSICAL ENDURANCE OF RATS INCREASED BY RUTIN
, 1970 (Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Brooks, K. M., Robbins, R C
openaire +2 more sources
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Actoprotective action of sodium 2-(tetrazol[1,5-c]quinazolin-5-ylthio)acetate in acute hemic hypoxia
Zaporožskij Medicinskij Žurnal, 2017 Enough energy and good oxygen supply of the organism is necessary to maintain high performance level. Hypoxic process develops rapidly during intense physical exertion. This prevents the execution of tasks, and under certain circumstances endangers human
O. Yu. Toziuk
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Physical education down under: Fusion or confusion [PDF]
, 2007 At the International Council for Health, Physical Education, Recreation, Sport and Dance (ICHPER-SD) Conference held in Wellington in October 2006, the authors presented a keynote titled: Physical Education Down Under: Fusion or Confusion.
Culpan, Ian, Grant, Bevan C.
core
ENDURANCE OF RATS WITH DISBIOZ IN EMOTIONAL-PHYSICAL STRESS
Medical academic journal, 2019 Stress loads in sport lead to the development of functional disorders of various body systems, including the digestive system. The use of pharmacological preparations for correction of dysbiotic states is very often. The aim of this work was to study the physical endurance of rats with dysbiosis with decreased and increased intestinal circadian rhythm (
A F Safonova +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Regulation of performance during endurance competition lecture
, 2022 Presentation at European Athletics Endurance Conference, Leeds ...
Renfree, Andrew
core +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source