Results 111 to 120 of about 4,724,720 (298)

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

open access: yesFEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez   +4 more
wiley   +1 more source

The Influence of Nordic Walking on Physical Fitness of Elderly People

open access: yesBaltic Journal of Sport and Health Sciences, 2018
Research background and hypothesis. Nordic Walking is a form of physical activity which is rapidly gaining its popularity and is suitable for people of various ages and health conditions.
Vaida Šokelienė   +1 more
doaj   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

open access: yesFEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata   +3 more
wiley   +1 more source

Age-Dependent Differences of Paraspinal Muscle Endurance and Morphology in Chinese Community Population Without Chronic Low Back Pain

open access: yesGlobal Spine Journal
Study Design: Cross-sectional study. Objectives: Our aim was to describe age-dependent changes of lumbar paraspinal muscle endurance and morphology in Chinese healthy population.
Gengyu Han MD   +7 more
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

open access: yesAging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

The distance-time relationship and its use in endurance training and performance [PDF]

open access: yes, 2015
The aims of this thesis were to develop a time efficient field test of the distance-time relationship, assess its validity, reliability and sensitivity and utilise the test to monitor and prescribe endurance training in distance runners. Laboratory-based
Galbraith, Andy
core  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

open access: yesAging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Biochemical aspects of KB-28 compound on physically loaded study subjects

open access: yesCurrent Issues in Pharmacy and Medical Sciences, 2019
In previous studies of actoprotective activity of 5-R-thio-tetrazolo[1,5]quinazoline derivatives in normal and complicated experimental conditions, sodium 2-(tetrazolo [1,5-c]quinazoline-5-ylthio)acetate (KB-28) was found to be the leader of the ...
Toziuk Olena   +7 more
doaj   +1 more source

Home - About - Disclaimer - Privacy