Results 51 to 60 of about 1,281,166 (254)

Creating a suitable physical environment at the institutions of higher education considering the needs of students with disabilities / Aukštųjų mokyklų fizinės aplinkos pritaikymas neįgaliųjų reikmėms

Mokslas: Lietuvos Ateitis, 2011
The main purpose of this work is to develop a model for meas­uring the suitability of a physical environment at the institu­tions of higher education considering the needs of students with disabilities.
Dalė Pilipavičiūtė, Gintautas Ambrasas   +1 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Escalas de Medida da Percepção da Qualidade do Ambiente Hospitalar - Um Estudo em Unidades de Dor

Psicologia: Teoria e Pesquisa
RESUMOEste estudo desenvolve e valida duas escalas de medida da percepção da qualidade do ambiente hospitalar: físico e sócio-funcional. Participaram 122 utilizadores de Unidades de Dor Portuguesas.
Rita Morais, Cláudia Campos Andrade, Sónia Bernardes, Cícero Roberto Pereira   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

After the Move to a New Campus—Effects on Students’ Satisfaction with the Physical and Learning Environment

Education Sciences, 2020
Few empirical studies in higher education consider the importance of the physical environment on students’ satisfaction with the learning environment. The present study first examined the effects of a move to a new campus on students’ satisfaction with ...
Andreia P. Costa, Georges Steffgen
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Assessing the Quality of Physical Environments of Early Childhood Schools within the Cape Coast Metropolis in Ghana Using a Sequential Explanatory Mixed-Methods Design

European Journal of Investigation in Health, Psychology and Education, 2020
(1) Background: The last few decades have seen researchers giving considerable attention to the physical context of early childhood care and development (ECCD) centers because many of the underlying processes that link physical context are quite similar ...
Salome Amissah-Essel, John Elvis Hagan, Thomas Schack   +2 more
doaj   +1 more source

The environment and physical activity.

, 2014
Until recently, obesity research has mainly focused on biological and behavioral factors. However, there is growing agreement among researchers that the social and physical environment may play an important role as well. Certain aspects of the environment may promote or discourage physical activity and therefore have an influence on children’s body ...
D'Haese, Sara, Cardon, Greet, Deforche, Benedicte   +2 more
openaire   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source