Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner+6 more
wiley +1 more source
Exercise can improve physical self perceptions in adolescents with low motor competence [PDF]
Adolescents with low motor competence have diminished perceptions of their physical self and tend to avoid physical activities. This study examined the outcomes of an exercise intervention that focused on improving aerobic fitness, strength, and self ...
Chivers, Paola+3 more
core +1 more source
Impact of exercise-nutritional state interactions in patients with type 2 diabetes
Introduction This study examines the role of nutritional status during exercise training in patients with type 2 diabetes mellitus by investigating the effect of endurance-type exercise training in the fasted versus the fed state on clinical outcome ...
Calders, Patrick+9 more
core +1 more source
The influence of the breast on physical activity participation in females [PDF]
Background:The importance of physical activity is well known.1 However, previous research suggests that breast movement during exercise can be painful, embarrassing, and anecdotally deter exercise participation.2,3 Therefore, this research investigates ...
Burnett, Emma+2 more
core +2 more sources
Understanding and measuring mechanical signals in the tumor stroma
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz+3 more
wiley +1 more source
Predicting objectively assessed physical activity from the content and regulation of exercise goals: evidence for a mediational model [PDF]
Grounded in self-determination theory (Deci & Ryan, 2000), the purpose of this work was to examine effects of the content and motivation of adults’ exercise goals on objectively assessed moderate-to-vigorous physical activity (MVPA).
Sebire, Simon J+2 more
core +1 more source
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi+2 more
wiley +1 more source
Parental exercise is associated with Australian children\u27s extracurricular sports participation and cardiorespiratory fitness : a cross-sectional study [PDF]
Background: The relationship between parental physical activity and children\u27s physical activity and cardiorespiratory fitness has not been well studied in the Australian context.
Blizzard, Leigh+4 more
core +4 more sources
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik+3 more
wiley +1 more source
Can a Home-based Cardiac Physical Activity Program Improve the Physical Function Quality of Life in Children with Fontan Circulation? [PDF]
Objective Patients after Fontan operation for complex congenital heart disease (CHD) have decreased exercise capacity and report reduced health-related quality of life (HRQOL). Studies suggest hospital-based cardiac physical activity programs can improve
Danduran, Michael E.+5 more
core +1 more source