Results 81 to 90 of about 648,571 (265)

Comparison of the Effect of Concurrent Moderate-Intensity Continuous Training and High-Intensity Interval Training with High-Intensity Interval Training Alone on Body Composition, Cortisol and Mental Health of Overweight 16-19-Year-old Male Students [PDF]

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk
Introduction: Being overweight is associated with increased cortisol secretion, along with heightened anxiety and depression. This study aimed to compare the effect of six weeks of concurrent moderate-intensity continuous training (MICT) and high ...
Fateme Tahsinin, Ali Heidarian Pour, Elnaz Shokri   +2 more
doaj  

Loss of popdc3 Impairs Mitochondrial Function and Causes Skeletal Muscle Atrophy and Reduced Swimming Ability in Zebrafish

Journal of Cachexia, Sarcopenia and Muscle
Background The Popeye domain containing 3 (POPDC3) protein is essential for the maintenance of skeletal muscle homeostasis. POPDC3 is a pathogenic variant gene of limb‐girdle muscular dystrophy (LGMD), and its variants lead to LGMDR26.
Chen‐Chen Sun, Zhang‐Lin Chen, Dong Yang, Jiang‐Ling Xiao, Xiang‐Tao Chen, Xi‐Yang Peng, Xiu‐Shan Wu, Chang‐Fa Tang   +7 more
doaj   +1 more source

Comparative analysis of sports workers and kinesiologists: a paradox of similar jobs but distinct professional profiles

Human Movement
Purpose Recently, in Italy, two professions have been defined in the field of sports and physical activities: the sports worker, trained by sports organisations, and the kinesiologist, who holds a degree in exercise and sports sciences.
Giovanni Esposito, Rosario Ceruso, Giuseppe Giardullo, Sara Aliberti, Gaetano Raiola   +4 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Qualitative assessment of mobility in older adults: a scoping review of process-oriented behavioural criteria

European Review of Aging and Physical Activity
Background/Objectives Mobility decline is a strong predictor of falls, fractures, and disability in older adults and is associated with sarcopenia, kinesiophobia, reduced physical activity, and poorer quality of life. Early identification is essential to
Natalie Lander, Costas Glavas, Anoohya Gandham, Ana Maria Contardo Ayala, L. Eduardo Cofré Lizama, Yuxin Zhang, Jackson Fyfe, Tao Zhou, David Scott, Robin M. Daly   +9 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Comparison of the effect of 8 weeks of aerobic and combined training on serum levels of leptin and glucose in type 2 diabetic men

مجله دانشگاه علوم پزشکی گرگان, 2015
Background and Objective: Leptin has a key role in obesity and type 2 of diabetes. This study was done to compare the effects of eight weeks aerobic and combined training on serum levels of leptin and glucose in type 2 diabetic men. Method: This clinical
Tadibi V, Behpour N, Rahimi MA, Rashidi S, Delbari ME, Usefipour P, Bayat Z   +6 more
doaj  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source