Results 91 to 100 of about 648,571 (265)

Creating customized chatbots with ChatGPT to promote physical activity: a mini review

Frontiers in Digital Health
Artificial intelligence (AI) chatbots powered by large language models (LLMs) such as ChatGPT offer a promising approach for delivering scalable, personalized physical activity interventions.
Liam O’Malley, Aidan Halley, Amanda Willms, India Edwards, Sam Liu   +4 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Comparative effectiveness of protein or protein-related supplementation combined with resistance or functional exercise for sarcopenia in older adults: a systematic review and network meta-analysis

Frontiers in Nutrition
BackgroundResistance and functional exercise are core non-pharmacological strategies for sarcopenia management. Protein or protein-related supplementation is commonly used to support exercise-induced adaptations, but the comparative effects of different ...
Boran Yang, Xueyi Chen, Gaiping Yuan, Xinxin Zhang, Dongsheng Lu   +4 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Neural network model for prediction of possible sarcopenic obesity using Korean national fitness award data (2010–2023)

Scientific Reports
Sarcopenic obesity (SO) is characterized by concomitant sarcopenia and obesity and presents a high risk of disability, morbidity, and mortality among older adults.
Jun-Hyun Bae, Ji-won Seo, Xinxing Li, SoYoung Ahn, Yunho Sung, Dae Young Kim   +5 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

The association between device-measured sitting time and cardiometabolic health risk factors in children

BMC Public Health
Background There is limited evidence of the associations between postural-derived sitting time, waist-worn derived sedentary time and children’s health and the moderation effect of physical activity (PA).
Ana María Contardo Ayala, Nicola D. Ridgers, Anna Timperio, Lauren Arundell, David W. Dunstan, Kylie D. Hesketh, Robin M. Daly, Jo Salmon   +7 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Physical exercise in liver diseases

Hepatology
Liver diseases contribute to ~2 million deaths each year and account for 4% of all deaths globally. Despite various treatment options, the management of liver diseases remains challenging. Physical exercise is a promising nonpharmacological approach to maintain and restore homeostasis and effectively prevent and mitigate liver diseases. In this review,
Yunwei Zhang, Chunyan Cao, Chaofan Li, Russell G. Witt, Hai Huang, Allan Tsung, Hongji Zhang   +6 more
openaire   +3 more sources

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source