Results 141 to 150 of about 538,774 (311)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Physical functioning in old age : Temporal trends and geographical variation in Sweden

, 2014
ADL disability is an age-related condition that leads to poor quality of life, increased health-related care costs, and increased mortality. The proportion of older adults are increasing worldwide, and it is therefore important both for society and the ...
Sjölund, Britt-Marie,, von Strauss, Eva
core  

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Effect of elevated depressive symptoms during adolescence on health-related quality of life in young adulthood—a six-year cohort study with repeated exposure measurements

Frontiers in Pediatrics
ObjectivesDepression is a major contributor of young people's burden of disease. In this study we aim to estimate the effect of elevated depressive symptoms on physical health-related quality of life.DesignWe used self-reported information from the ...
Jascha Wiehn, Tobias Kurth, Ulrike Ravens-Sieberer, Christof Prugger, Marco Piccininni, Marco Piccininni, Franziska Reiss   +6 more
doaj   +1 more source

The relationship between leisure time physical activity and health-related fitness : a single-blinded study

, 2013
Includes abstract.Includes bibliographical references.Mature adults are at risk of an accelerated age-related reduction in physical function. Declines in aerobic power, functional strength, motor abilities, flexibility and health-related quality of life ...
Beutel, Anita
core  

Effects of Resistance Training Frequency on Physical Functioning and Quality of Life in Prostate Cancer Survivors: A Pilot Randomized Controlled Trial

, 2015
Background: Resistance training (RT) improves physical functioning and quality of life in prostate cancer survivors but the optimal frequency of RT is unknown.
Norris, Mary K
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Physical functioning and mindfulness skills training in chronic pain: a systematic review

, 2019
William Jackson,1 Emily L Zale,2 Stanley J Berman,3 Alberto Malacarne,1 Amy Lapidow,4 Michael E Schatman,5,6 Ronald Kulich,1,7,* Ana-Maria Vranceanu2,* 1Department of Diagnostic Sciences, Tufts University School of Dental Medicine, Boston, MA, USA ...
Zale EL, Lapidow A, Schatman ME, Malacarne A, Berman SJ, Jackson W, Vranceanu AM, Kulich R   +7 more
core  

Intelligent Tutoring Systems for Adult Learning in STEM Disciplines

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley   +1 more source