Results 71 to 80 of about 28,137,191 (312)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Semantics of Computable Physical Models
Studia Logica, 2023 AbstractThis article reformulates the theory of computable physical models, previously introduced by the author, as a branch of applied model theory in first-order logic. It provides a semantic approach to the philosophy of science that incorporates aspects of operationalism and Popper’s degrees of falsifiability.
openaire +2 more sources
Unbiased Least-Squares Modelling
Mathematics, 2020 In this paper we analyze the bias in a general linear least-squares parameter estimation problem, when it is caused by deterministic variables that have not been included in the model.
Marta Gatto, Fabio Marcuzzi
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Physics-Based Explosion Modeling
Graphical Models, 2001 Summary: Explosions are among the most common special effects employed in the entertainment industry. Producing real explosions, however, is costly and potentially dangerous and special effects technicians have been turning to software to generate explosion sequences.
Byron Bashforth, Yee-Hong Yang
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Numerical and physical modelling of tundish slag entrainment in the steelmaking process
, 2017 CITATION: Mabentsela, A., Akdogan, G. & Bradshaw, S. 2017. Numerical and physical modelling of tundish slag entrainment in the steelmaking process. Journal of the Southern African Institute of Mining and Metallurgy, 117(5):469-483, doi:10.17159/2411-9717/
A. Mabentsela, G. Akdogan, S. Bradshaw
semanticscholar +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Modeling of physical network systems [PDF]
Systems & Control Letters, 2017 20 ...
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