Results 71 to 80 of about 3,121,428 (243)

Cosmologies with a time dependent vacuum

open access: yes, 2011
The idea that the cosmological term, Lambda, should be a time dependent quantity in cosmology is a most natural one. It is difficult to conceive an expanding universe with a strictly constant vacuum energy density, namely one that has remained immutable ...
Basilakos S   +28 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Higher Spin de Sitter Hilbert Space [PDF]

open access: yes, 2017
We propose a complete microscopic definition of the Hilbert space of minimal higher spin de Sitter quantum gravity and its Hartle-Hawking vacuum state.
Anninos, Dionysios   +3 more
core   +2 more sources

General Gauge Mediation in 5D

open access: yes, 2010
We use the "General Gauge Mediation" formalism to describe a 5D setup with an $S^{1}/Z_{2}$ orbifold. We first consider a model independent SUSY breaking hidden sector on one boundary and generic chiral matter on another. Using the definition of GGM, the
McGarrie, Moritz, Russo, Rodolfo
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

Association Between Oral Hypofunction and Physical Frailty Among Korean Older Adults with Preserved Cognitive and Functional Status

open access: yesApplied Sciences
The oral cavity performs several functions that are essential for sustaining life and carrying out daily activities. Given the importance of maintaining functional abilities for healthy aging, exploration of the adverse health outcomes that may result ...
Ha-Yeoung Kim, Jiyoun Kim, Jun-Seon Choi
doaj   +1 more source

The Tourist Activity of Youth in Podkarpackie region as a Resource Supporting Their Personal Growth

open access: yesStudia Paedagogica Ignatiana, 2017
Tourism is one of the forms of human activity which has special importance for the progress of personality, self-education and preparing man for performing a variety of social roles, functions and duties.
Marcin Warchoła
doaj   +1 more source

Exact solvability of the quantum Rabi models within Bogoliubov operators

open access: yes, 2012
The quantum Rabi model can be solved exactly by the Bargmann transformation from real coordinate to complex variable recently [Phys. Rev. Lett. \textbf{107}, 100401 (2011)].
Chen, Qing-Hu   +4 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

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