Results 201 to 210 of about 70,022 (267)

Identifying effective behavior change techniques in interventions for enhancing the implementation of school-based policies and/or practices to prevent chronic disease in students: a secondary analysis of a systematic review. [PDF]

Transl Behav Med
Lee DCW, O'Brien KM, Presseau J, Yoong S, McCrabb S, McDiarmid K, Lecathelinais C, Wolfenden L, Hodder RK.   +8 more
europepmc   +1 more source

Ion‐Driven Regulation of Ca2+ Flow by Ti/Zn Composite Activates ERK/MAPK Signaling and Maintains Mitochondrial Homeostasis to Promote Macrophage‐Mediated Bone Regeneration

Advanced Science, EarlyView.
A 3D‐printed interpenetrating Ti/Zn composite enables sustained Zn2+ release to regulate intracellular Ca2+ redistribution, preserve mitochondrial homeostasis, activate ERK/MAPK signaling, and promote M2 macrophage polarization, thereby enhancing osteoimmune‐mediated bone regeneration and peri‐implant osseointegration.
Wanyi Huang, Qiyue Zhang, Yueyang Qiu, Haocheng Suo, Zengqian Liu, Bing Bai, Qiang Wang, Qing Zhou   +7 more
wiley   +1 more source

Epigenome-wide exploratory study of blood DNA methylation and markers of physical performance indicates subtle differences across levels of cardiovascular fitness. [PDF]

Front Physiol
Torma F, Santos E, Jókai M, Bábszky Z, Bábszky G, Mozaffaritabar S, Herai RH, Pinho RA, Higuchi M, Gu Y, Radák Z.   +10 more
europepmc   +1 more source

AARS1‐Mediated RUNX3 K193 Lactylation Enhances the Activation and Cytotoxicity of CD8+T Cells in Smoking‐Related Emphysema

Advanced Science, EarlyView.
Exposure to CS causes an elevation of AARS1 levels, which increases the levels of RUNX3 lactylation at the K193 site and increases protein levels of RUNX3 through inhibition of autolysosomal degradation. Elevated RUNX3 levels promote CD8+T cell activation and augment their cytotoxicity, which induces alveolar epithelial cell death and facilitates the ...
Ying Zhu, Jiaheng Lin, Yifan Li, Qiaoqiao Zhou, Min Yu, Cheng Cheng, Kang Chang, Dang Lin, Tao Bian, Yan Wu, Lu Lu, Haibo Xia, Qizhan Liu   +12 more
wiley   +1 more source

Advancing the bioassay ontology through integrated PK/PD and safety pharmacology representation. [PDF]

J Biomed Semantics
Glenny-Pescov J, Chung C, Ross N, Hu J, Sinclair M, Khurshid R, Karlsson A, Schürer SC.   +7 more
europepmc   +1 more source

Unified Informational Physics Ontology

Unified Informational Physics Ontology Kevin L. Brown, Independent ResearcherNovember 202510.5281/zenodo.17623979 Abstract This document presents the Unified Informational Physics Ontology — a master reference that gathers the entire Triune Harmonic Dynamics (THD) and Informational Physics corpus into one coherent, falsifiable architecture ...
openaire   +1 more source

Fibrillarin Resists Cellular Senescence Via SIRT1‐Dependent Nicotinamide Metabolism and Its Inhibition Sensitizes Senolytic Therapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
FBL directly binds to and stabilizes SIRT1 by blocking its ubiquitin‐proteasome degradation, thereby sustaining nicotinamide metabolism and redox homeostasis to counteract cellular senescence in ESCC. Genetic and pharmacological suppression of FBL sensitizes tumor cells to senolytic therapy.
Xing Jin, Hong Liu, Ling Gao, Lei Liu, Ji‐Bin Liu, Xiaoxia Jin, Ming‐Song Wang, Dan Liu, Li Feng, Wen‐Lian Chen   +9 more
wiley   +1 more source

Debris flow disaster information representation and perception based on knowledge graphs and virtual geographic environments. [PDF]

Sci Rep
Zhang Z, Fu H, Zhang J, Zhang Y, Gu Z.
europepmc   +1 more source

A pH‐Switchable Cerium Single‐Atom Enzyme for Peri‐Implantitis Therapy via JAK‐STAT Signaling Axis‐Mediated Macrophage Reprogramming

Advanced Science, EarlyView.
A pH‐switchable cerium single‐atom enzyme is developed for stage‐specific peri‐implantitis therapy. Acidic conditions trigger antibacterial peroxidase‐like activity, whereas neutral conditions activate an antioxidant superoxide dismutase ‐ and catalase ‐like enzymatic relay. This microenvironment‐adaptive catalytic strategy suppresses the IL‐6/JAK‐STAT
Xiaomin Xia, Haojie Wu, Xingyun Li, Lining Liu, Kaiqing Song, Jinpei Cui, Jie Liu, Jiaxuan Yin, Emtiaz Ahmed, Yusuke Yamauchi, Xue Li   +10 more
wiley   +1 more source

Ontology-based annotation and fuzzy recommendation for community formation in smart city knowledge platforms. [PDF]

Front Artif Intell
Hawash A, Bottoni P, Avola D.
europepmc   +1 more source