Results 61 to 70 of about 8,710,850 (247)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

To have value, comparisons of high-throughput phenotyping methods need statistical tests of bias and variance

Frontiers in Plant Science
The gap between genomics and phenomics is narrowing. The rate at which it is narrowing, however, is being slowed by improper statistical comparison of methods.
Justin M. McGrath, Justin M. McGrath, Matthew H. Siebers, Matthew H. Siebers, Peng Fu, Peng Fu, Stephen P. Long, Stephen P. Long, Stephen P. Long, Carl J. Bernacchi, Carl J. Bernacchi, Carl J. Bernacchi   +11 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Guide to Information Sources in the Physical Sciences

Issues in Science and Technology Librarianship, 2000
The article reviews the book Guide to Information Sources in the Physical Sciences. Englewood, Colorado: Libraries Unlimited, Inc. 2000. 227 pp. 1-56308-751-0 by David Stern. 
Kitty Porter
doaj   +1 more source

The Impact of Physical Activity and Sport on Mental Health

التربية الرياضية, 2020
Scientists have researched different aspects of physical exercise and sports and their impact on the health of a person. However, the impact of physical activity and sport on mental health has not been looked into extensively.
Tamadher abdluaziz Muhsen, Muroj abdulaziz Muhsen   +1 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

A physical sciences network characterization of non-tumorigenic and metastatic cells

Scientific Reports, 2013
To investigate the transition from non-cancerous to metastatic from a physical sciences perspective, the Physical Sciences–Oncology Centers (PS-OC) Network performed molecular and biophysical comparative studies of the non-tumorigenic MCF-10A and ...
David B. Jenolyn F. Wadih Shashanka Joseph E. Robert H. Agus Alexander Arap Ashili Aslan Austin Backman Be, D. Agus, J. Alexander, W. Arap, Shashanka Ashili, J. Aslan, R. Austin, V. Backman, K. Bethel, Richard Bonneau, Wei-Chiang Chen, Chira Chen-Tanyolac, Nathan C. Choi, S. Curley, Matthew R. Dallas, D. Damania, P. Davies, P. Decuzzi, Laura E. Dickinson, Luis D. Estévez-Salmerón, V. Estrella, M. Ferrari, C. Fischbach, Jasmine Foo, S. Fraley, C. Frantz, A. Fuhrmann, P. Gascard, R. Gatenby, Yue Geng, S. Gerecht, R. Gillies, B. Godin, W. Grady, Alex Greenfield, Courtney Hemphill, B. Hempstead, Abigail C. Hielscher, W. Hillis, E. Holland, Arig Ibrahim-Hashim, T. Jacks, Roger H. Johnson, A. Joo, J. Katz, L. Kelbauskas, C. Kesselman, M. King, K. Konstantopoulos, Casey M. Kraning-Rush, P. Kuhn, K. Kung, Brian J. Kwee, J. Lakins, G. Lambert, David Liao, J. Licht, J. Liphardt, Liyu Liu, M. Lloyd, A. Lyubimova, P. Mallick, J. Marko, O. McCarty, D. Meldrum, F. Michor, S. Mumenthaler, V. Nandakumar, T. O’Halloran, Steve Oh, R. Pasqualini, M. Paszek, K. Philips, Christopher S. Poultney, K. Rana, Cynthia A. Reinhart-King, R. Ros, G. Semenza, P. Senechal, M. Shuler, Srimeenakshi Srinivasan, J. Staunton, Yolanda Stypula, H. Subramanian, T. Tlsty, G. Tormoen, Yiider Tseng, A. van Oudenaarden, S. Verbridge, Jenny C. Wan, V. Weaver, J. Widom, C. Will, D. Wirtz, Jonathan W. Wojtkowiak, Pei-Hsun Wu   +95 more
semanticscholar   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source