Results 101 to 110 of about 5,661,908 (250)

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Frequency of Musculoskeletal Impairment in Different Professionals Teachers, Bankers and Medical Professional

Journal Riphah College of Rehabilitation Sciences, 2017
Background: Musculoskeletal impairments are leading cause of discomfort and work inefficiency. There is dire need to recommend a postural care program to all those who have at risk for developing such impairments.
Zahoor Ahmad, Ibraheem Zafar, Muhammad Saad Shafique, Sabaat Hassan, Iqbal Tariq, Arshad Nawaz Malik   +5 more
doaj  

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Perception of Undergraduate Rehabilitation and Nursing Students of Khyber Medical University, Peshawar, Pakistan, Regarding an Effective Teacher: A Cross-sectional Study

Journal Riphah College of Rehabilitation Sciences
: Background: Effective teaching is crucial in medical education, where instructor’s performance and personality attributes significantly impact student learning.
Sapna Ali Khan, Uzma Amin, Hoor Bakht, Haider Darain, Hazrat Bilal, Aamna Bibi   +5 more
doaj  

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Awareness of Modifiable Risk Factors Associated with Cardiovascular Diseases among Post-Menopausal Females and Role of Physical Therapist in preventive Strategies

Journal Riphah College of Rehabilitation Sciences
Background: Menopause significantly increases the risk of cardiovascular diseases (CVD) due to modifiable risk factors such as visceral obesity, dyslipidemia, impaired glucose regulation, non-alcoholic fatty liver disease, and hypertension, all ...
Uzba Bilal, Somia Faisal
doaj  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

THE ROLE OF PHYSICAL THERAPY IN DIMINISHING THE EFFECTS OF THE CONGENITAL HEART DEFECT - CASE STUDY

Sport şi Societate, 2014
In ROMANIA, fetal abnormalities are the cause of 20-30% of infant mortality, being second only to prematurity - 53% in 2005. The restriction of the fetal growth represents the main cause for intrauterine fetal death (60-70%), and the second cause of ...
Croitoru Ramona, Balint Nela Tatiana
doaj  

Three Perspectives on Physical Therapist Managerial Work

, 2002
Background and Purpose. The nature of managerial work in the commercial sector has not been studied since the 1970s, and little is known about the work of managers in the health care sector.
D Sue Schafer
core   +1 more source