Results 91 to 100 of about 109,940 (315)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Physical Therapist Management of Patients With Suspected or Confirmed Osteoporosis: A Clinical Practice Guideline From the Academy of Geriatric Physical Therapy

, 2022
A clinical practice guideline on physical therapist management of patients with suspected or confirmed osteoporosis was developed by a volunteer guideline development group (GDG) that was appointed by the Academy of Geriatric Physical Therapy (APTA ...
Hartley, Gregory W., Avin, Keith G., Robert W. Nithman, Keith G. Avin, Nithman, Robert W, Lindsey, Carleen, Carleen Lindsey, Avin, Keith G, Nithman, Robert W., Betz, Sherri R., Fuchs, Robyn K, Betz, Sherri R, Hartley, Gregory W, Gregory W. Hartley, Kathryn E. Roach, Roach, Kathryn E., Sherri R. Betz, Robyn K. Fuchs, Fuchs, Robyn K., Roach, Kathryn E   +19 more
core   +1 more source

PHYSICAL THERAPY FOLLOWING ANTERIOR CERVICAL DISCECTOMY AND FUSION: A STUDY OF CURRENT CLINICAL PRACTICE AND THERAPIST BELIEFS

International Journal of Physiotherapy, 2015
Background: Anterior cervical discectomy and fusion (ACDF) is a commonly performed surgical procedure. However, there is substantial debate regarding the role of physical therapy following this procedure.
Brian T. Swanson , Robin R. Leger
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Can a Community of Practice Improve Physical Therapists’ Self-Perceived Practice in Developmental Coordination Disorder?

, 2017
Background. Communities of practice (CoPs) are useful knowledge translation (KT) strategies, but little is known about their impact on physical therapists’ self-perceived practice. Purpose.
Camden, Chantal, Berbari, Jade, Léa Héguy, Chantal Camden, Karen Hurtubise, Lisa M. Rivard, Jade Berbari, Hurtubise, Karen, Héguy, Léa   +8 more
core   +1 more source

Occupational therapists’ views of using a virtual reality interior design application within the pre-discharge home visit process [PDF]

, 2014
This article has been made available through the Brunel Open Access Publishing Fund.Background: A key role of Occupational Therapists (OTs) is to carry out pre-discharge home visits (PHV) and propose appropriate adaptations to the home environment, to ...
Harvey, M, Atwal, A, Money, A
core   +1 more source

Cardiopulmonary Resuscitation–attitudes and awareness among physical therapists of Karachi–A Cross-sectional Survey

Journal Riphah College of Rehabilitation Sciences, 2022
Background: The prime objective of CPR is to maintain enough circulation to preserve existence till specialized treatment is provided. As mentioned, early CPR is an essential aspect in the chain of survival in Emergency Cardiovascular Care (ECC ...
Sobia Hassan, Saad Saleem, Fahad Farooq, Amaila Fazal, Sabika Minhaj, Muhammad Khurram Amin   +5 more
doaj  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Survey of physical therapists' attitudes, knowledge, and behaviors regarding diagnostic imaging

, 2021
Click on the DOI link to access the article (may not be free).OBJECTIVE: The purpose of this study was to describe physical therapists' attitudes, knowledge, and behaviors regarding the use of diagnostic imaging.
Manske, Robert C., Beneck, George J., Rundell, Sean D., Maitland, Murray E.   +3 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source