Results 71 to 80 of about 109,940 (315)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Exploration of the experiences of physical therapists who identify as LGBTQIA+: Navigating sexual orientation and gender identity in clinical, academic, and professional roles

, 2022
Objective: The purpose of this study was to explore physical therapy through the stories of physical therapists who identify as lesbian, gay, bisexual, transgender, queer, intersex, asexual, and other related identities (LGBTQIA+) to consider how the ...
Hammond, J., Setchell, J., Brown, D., Whittaker, J.L., Miciak, M., Ross, M.H., Chipchase, L., Bezner, J., Wright, A.   +8 more
core   +1 more source

Role of physical therapists in providing care to older adults in welfare shelters during the hyper-acute phase of a disaster: lessons learned in Wajima City, Japan, after the 2024 Noto Peninsula earthquake

Frontiers in Disaster and Emergency Medicine
Natural disasters pose significant challenges to affected communities, particularly vulnerable populations such as older adults. The aftermath of the Great East Japan Earthquake highlighted the necessity of welfare shelters to provide essential care ...
Toshiki Abe, Hiroaki Saito, Hiroaki Saito, Chika Yamamoto, Yuichiro Eguchi, Yuichiro Eguchi, Kei Sato, Kei Sato, Misato Matsumoto, Misato Matsumoto, Kengo Hitachi, Kengo Hitachi, Sakiko Inoue, Tianchen Zhao, Michioki Endo, Toyoaki Sawano, Toyoaki Sawano, Akihiko Ozaki, Masaharu Tsubokura, Hiroyuki Beniya   +19 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

World Federation of Occupational Therapists' Position Statement on Telehealth

, 2014
The purpose of this document is to state the World Federation of Occupational Therapists’ (WFOT) position on the use of telehealth for the delivery of occupational therapy services.
World Federation of Occupational Therapists, Occupational Therapists, World Federation of   +1 more
core   +1 more source

Enhancing the quality of life for physical therapists: insights from a cross-sectional study

Frontiers in Public Health
BackgroundPhysical Therapy profession is known for its demanding physical requirements. This increases the risk of attrition and work-related accidents and disorders that affect physical therapists’ quality of life and work performance.
Rahaf Eid Al Ali, Sahab A. Alrowaishd, Elaf Z. Abu Thyab, Raghad K. Almarzuqi, Manal I. Al Awaji, Monira I. Aldhahi, Zizi M. Ibrahim, Zizi M. Ibrahim   +7 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Evaluation of Musculoskeletal Loads and Pain in Physical Therapists Treating Neurological Patients

The Indonesian Journal of Occupational Safety and Health
Introduction: Work-related musculoskeletal disorders (WRMDs) are one of the major health problems among physical therapists treating neurological patients.
Daehee Lee, Hyejoo Jeon
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source