Results 61 to 70 of about 5,694,457 (232)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Hand and wrist orthoses for adults with rheumatological conditions. Practice guidelines for occupational therapists. (Second Edition)

, 2020
This publication provides specific evidence-based recommendations which describe the most appropriate care or action to be taken by occupational therapists working with adults who may benefit from a hand or wrist orthosis as an intervention for a ...
Royal College of Occupational therapists
core   +4 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Accreditation of practice educators: An expectation too far ? [PDF]

, 2004
The successful completion of practice placements is essential to the education of occupational therapists; however, ensuring quality placements is challenging for occupational therapy educators.
Gallagher, M, McIntyre, A, Craik, C
core   +1 more source

Evaluation of Musculoskeletal Loads and Pain in Physical Therapists Treating Neurological Patients

The Indonesian Journal of Occupational Safety and Health
Introduction: Work-related musculoskeletal disorders (WRMDs) are one of the major health problems among physical therapists treating neurological patients.
Daehee Lee, Hyejoo Jeon
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Understanding Mechanobiology: Physical Therapists as a Force in Mechanotherapy and Musculoskeletal Regenerative Rehabilitation [PDF]

, 2016
Achieving functional restoration of diseased or injured tissues is the ultimate goal of both regenerative medicine approaches and physical therapy interventions.
Loghmani, M Terry, Loghmani, M. Terry, Thompson, William R, Warden, Stuart J., Warden, Stuart J, Thompson, William R., Ward, Samuel R., Scott, Alexander, Ward, Samuel R   +8 more
core   +1 more source

Knowledge, Attitudes and Practices of Clinical Physical Therapists Regarding Evidence Based Practice

Journal of Islamic International Medical College, 2022
Objective: To determine knowledge, attitudes and practices of Physical therapist towards Evidence Based Practice and to identify the barriers faced by them regarding their practice Study Design: A Cross Sectional Study.
Zoya Mehmood, Asmar Fatima, Bintal Wajeeh Satti, Huma Riaz, Suhail Karim, Tehmina Nazir   +5 more
doaj  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source