Results 51 to 60 of about 1,172,238 (266)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Hip Pain and Mobility Deficits-Hip Osteoarthritis: Revision 2017 Clinical Practice Guidelines Linked to the International Classification of Functioning, Disability and Health

康复学报, 2019
The Orthopaedic Section of the American Physical Therapy Association(APTA)has an ongoing effort to create evidence-based practice guidelines for orthopaedic physical therapy management of patients with musculoskeletal impairments described in the World ...
The Orthopaedic Section of the American Physical Therapy Association
doaj  

Tampa scale for kinesiophobia in individuals with knee osteoarthritis: a cross-sectional psychometric evaluation using item-level and exploratory factor analyses

Scientific Reports
This study evaluated floor and ceiling (F/C) effects within the Tampa Scale for Kinesiophobia (TSK) and examined item-level correlations with total TSK scores and pain intensity in individuals with knee osteoarthritis (KOA).
Prasert Sakulsriprasert, Tipwadee Bunprajun, Ninwisan Hengsomboon, Pichaya Hengsomboon, Pavinee Harutaichun, Chompunoot Suwanasri, Pinyada Warathanagasame, Chutiporn Thammajaree, Akenarin Chocknakawaro, Nattapa Ariyakitsakul   +9 more
doaj   +1 more source

EFFECT OF TRANSCRANIAL LASER ON SOMATOSENSORY INTEGRATION IN PATIENTS WITH NONSPECIFIC NECK PAIN: RANDOMIZED CONTROLLED TRIAL

International Journal of Physiotherapy, 2018
Background: Nonspecific neck pain is a frequent cause for adults to consult health care providers. Therefore, the physical therapist should always seek the most effective intervention(s) within the wide spectrum of treatments available, so this study was
Roshdy M. kamel , Ghada I. Mohamed, Ibrahim M. Moustafa , Ragia M. Kamel, Omaima M. Kattabei   +4 more
doaj   +1 more source

Physical therapy: A critique

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 1997
Some forms of physical therapy are used relatively frequently in the treatment of chronic musculoskeletal pain conditions, including the temporomandibular disorders. We found evidence that cold seems to be a useful treatment for postsurgical pain and swelling and that most patients being treated for most chronic musculoskeletal pain seem to do better ...
Faculty of Dentistry, McGill University. Montreal, Quebec, Canada ( host institution ), Feine, Jocelyne S, Widmer, Charles G, Lund, James P   +3 more
openaire   +3 more sources

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Heel Pain-plantar Fasciitis:Revision 2014 Clinical Practice Guidelines Linked to the International Classification of Functioning, Disability and Health

康复学报, 2019
The Orthopaedic Section of the American Physical Therapy Association(APTA)has an ongoing effort to create evidence-based practice guidelines for orthopaedic physical therapy management of patients with musculoskeletal impairments described in the World ...
The Orthopaedic Section of the American Physical Therapy Association
doaj  

Effects of forward shoulder elevation on spinal excursion at three different speeds

Scientific Reports
This study aims to investigate how varying shoulder movement speeds affect spinal mobility to enhance understanding of the trunk’s adaptive response to these perturbations.
Pichaya Hengsomboon, Ninwisan Hengsomboon, Pavinee Harutaichun, Sunee Bovonsunthonchai, Prasert Sakulsriprasert   +4 more
doaj   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source