Results 241 to 250 of about 7,865,495 (292)

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

Corynoxine Inhibits Tumor Growth via Targeting NQO1 and Modulating the PTPA–NQO1/PP2A Switch to Activate PP2A

Advanced Science, EarlyView.
Corynoxine exerts potent broad‐spectrum anticancer activity by directly targeting NQO1. This interaction dissociates the oncogenic NQO1‐PTPA complex, releasing PTPA to robustly activate the tumor suppressor PP2A. Consequently, downstream Raf/MEK/ERK and PI3K/AKT signaling pathways are suppressed, downregulating c‐Myc and driving tumor regression ...
Guoqing Hou, Li Lin, Mengjie Xia, Ruohan Liang, Yueyue Zhang, Linna Du, Xuan Cao   +6 more
wiley   +1 more source

Psychedelics and Ibogaine "Pain Medications" at the Pharmacy Counter: Implications for Pharmacy Practice. [PDF]

J Pain Res
Breve F, Berenato FJ, Pergolizzi JV, Varrassi G, Raffa RB.   +4 more
europepmc   +1 more source

When the Aorta Speaks: Multimodality Imaging and Heart Team Decision-Making in Complex Takayasu Arteritis. [PDF]

JACC Case Rep
Maejima Y.
europepmc   +1 more source

Retrospective Evaluation of Dual Specialty Ports in Therapeutic Apheresis. [PDF]

J Clin Apher
Swar-Eldahab M, Obeng-Gyasi B, Haste P, Krosin M.   +3 more
europepmc   +1 more source

Integrating family-based interventions into specialty court programs: qualitative guidance from sex trafficking specialty court participants and their supportive family members. [PDF]

Health Justice
Murnan A, Mahon J, Jackson G, Pate S, Thompson S, Stewart C, Brown J, Manchak S, Butsch Kovacic M.   +8 more
europepmc   +1 more source

Evaluation and Ranking for Scientific, Transparent and Applicable of Chinese Geriatrics Guidelines and Consensus Published in 2023. [PDF]

Aging Med (Milton)
Li D, Gao C, Huang X, Kang L, Dong B, Yue J, Specialized Committee for Geriatric Medicine of the STAR.   +6 more
europepmc   +1 more source

Understanding Ehlers-Danlos Syndrome: A Claims-Based Analysis of Healthcare Cost Patterns. [PDF]

J Health Econ Outcomes Res
Oyediran SA, Kim Y, Novikov Z, Krause TM.   +3 more
europepmc   +1 more source

Treating de Quervain's disease : a systematic review and meta-analysis comparing corticosteroid injections and hand therapy

, 2017
Cavaleri, Rocco (R18308), Te, Maxine (S32924), Chipchase, Lucinda S. (R17269), Schabrun, Siobhan M. (R17427)   +3 more
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