Results 121 to 130 of about 5,433 (285)
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Making Sense of Downward Causation in Manipulationism. With Illustrations from Cancer Research [PDF]
Many researchers consider cancer to have molecular causes, namely mutated genes that result in abnormal cell proliferation (e.g. Weinberg 1998); yet for others, the causes of cancer are to be found not at the molecular level but at the tissue level and ...
Malaterre, Christophe
core
Physicalism is the metaphysical thesis that everything is physical. According to this thesis, everything in the world, including chemical, biological, mental, and social entities and processes, is constituted by or results from physical entities and ...
Malaterre, Christophe
core +2 more sources
The Fractal Self and the Organization of Nature: The Daoist Sage and Chaos Theory
The interconnections between self and surroundings in Daoist thought have been explored in the past in a variety of contexts. This paper, however, explores the Daoist version of the relational self from the general perspective of chaos theory and, more ...
doaj +2 more sources
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
KNOWING OURSELVES AS EMBODIED, EMBEDDED, AND RELATIONALLY EXTENDED
What does it mean to know oneself, and what is the self that one hopes to know? This article outlines the implications of an embodied understanding of persons and some aspects of the “self” that are generally ignored when thinking about our selves.
doaj +2 more sources
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
ASTROPHYSICS AND CREATION: PERCEIVING THE UNIVERSE THROUGH SCIENCE AND PARTICIPATION
I explore how the notion of divine creation could be made understandable in a worldview dominated by empirical science. The crucial question concerns the empirical basis of belief in creation.
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RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
FRANK TIPLER'S PHYSICAL ESCHATOLOGY
. Frank L. Tipler's book The Physics of Immortality is a striking attempt by a scientist to resolve the conflict between theology and science on the basis of a physicalist position that identifies theology as a branch of physics, and that calculates God
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