Results 51 to 60 of about 9,167,519 (310)

Quantifying vegetation effects on landslide hazard using a physically based model: implications for catchment-scale prioritization and management

Frontiers in Forests and Global Change
Vegetation plays a critical role in slope stability, yet its effects on landslide hazard remain difficult to quantify at spatial scales relevant to management.
Dongyeob Kim
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

A Physically Based Runoff Model Analysis of the Querétaro River Basin

Journal of Applied Mathematics, 2014
Today the knowledge of physical parameters of a basin is essential to know adequately the rainfall-runoff process; it is well known that the specific characteristics of each basin such as temperature, geographical location, and elevation above sea level ...
Carlos Javier Villa Alvarado, Eladio Delgadillo-Ruiz, Carlos Alberto Mastachi-Loza, Enrique González-Sosa, Ramos Salinas Norma Maricela   +4 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

A Parameterized Water–Cloud Model Constrained by Physically Based Knowledge

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Effectively calibrating microwave scattering models and accurately simulating the soil–vegetation interaction of backscatter coefficients (σo) are prerequisites for improving soil moisture (SM) retrieval.
Zhuangzhuang Feng, Xingming Zheng, Xiaofeng Li, Chunmei Wang, Zui Tao, Si Chen, Jinfeng Song, Tianhao Guo   +7 more
doaj   +1 more source

Physics-Based Modeling of the Pregnant Woman [PDF]

, 2010
High quality obstetric images have become readily available with fast magnetic resonance imaging protocols or new 3D ultrasound probes. These obstetric images provide detailed information which can be used to create realistic models of the fetus at different stages of gestation.
Juan Pablo de la Plata Alcalde, Lazar Bibin, Jérémie Anquez, Tamy Boubekeur, Elsa D. Angelini, Isabelle Bloch   +5 more
openaire   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Improving flood forecasting capability of physically based distributed hydrological models by parameter optimization [PDF]

Hydrology and Earth System Sciences, 2016
Physically based distributed hydrological models (hereafter referred to as PBDHMs) divide the terrain of the whole catchment into a number of grid cells at fine resolution and assimilate different terrain data and precipitation to different cells.
Y. Chen, J. Li, H. Xu
doaj   +1 more source