Results 71 to 80 of about 28,566 (291)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

The patient-physician interactions as seen by undergraduate medical students

open access: yesSão Paulo Medical Journal, 2001
CONTEXT: The interaction between a physician and his or her patient is complex and occurs by means of technical performance and through a personal relationship.
Leandro Yoshinobu Kiyohara   +10 more
doaj   +1 more source

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito   +8 more
wiley   +1 more source

Why do some physicians choose to tackle inequities in healthcare?

open access: yesInternational Journal for Equity in Health, 2018
Background Despite the reputation of Canada’s healthcare system as being accessible to all Canadians, certain populations continue to face inequities within our healthcare system.
Victoria Nkunu, Kevin J. McLaughlin
doaj   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang   +4 more
wiley   +1 more source

A Physician's Guide to Motivational Interviewing [PDF]

open access: yes, 2018
Recommending lifestyle changes to patients is a crucial part of a primary care physician's role. Guiding patients to make behavioral change is a challenge physicians must face on a daily basis, and based on current literature, it can be delivered more ...
Gallegos, Anthony J
core  

Sex-Role Stereotypes in Medicine [PDF]

open access: yes, 1987
I argue for compatibility between feminism and medicine by developing a model of the physician-other relationship which is essentially egalitarian.
Mahowald, Mary B., Mary B. Mahowald
core   +1 more source

Reinforcing the Foundations of Family Medicine in Egypt: Ethics, Prevention, and Patient Safety [PDF]

open access: yesThe Egyptian Family Medicine Journal
Family medicine plays a pivotal role in delivering comprehensive, ethical, and preventive healthcare. The studies in this issue highlight important gaps and opportunities in medical ethics, chronic disease prevention, and medication safety within ...
Nagwa Hegazy
doaj   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs   +7 more
wiley   +1 more source

The Nature and Limits of the Physician's Professional Responsibilities: Surgical Ethics, Matters of Conscience, and Managed Care [PDF]

open access: yes, 2004
The nature and limits of the physician's professional responsibilities constitute core topics in clinical ethics. These responsibilities originate in the physician's professional role, which was first examined in the modern English-language literature ...
McCullough, Laurence B.
core  

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