ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source
The patient-physician interactions as seen by undergraduate medical students
CONTEXT: The interaction between a physician and his or her patient is complex and occurs by means of technical performance and through a personal relationship.
Leandro Yoshinobu Kiyohara +10 more
doaj +1 more source
Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito +8 more
wiley +1 more source
Why do some physicians choose to tackle inequities in healthcare?
Background Despite the reputation of Canada’s healthcare system as being accessible to all Canadians, certain populations continue to face inequities within our healthcare system.
Victoria Nkunu, Kevin J. McLaughlin
doaj +1 more source
Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang +4 more
wiley +1 more source
A Physician's Guide to Motivational Interviewing [PDF]
Recommending lifestyle changes to patients is a crucial part of a primary care physician's role. Guiding patients to make behavioral change is a challenge physicians must face on a daily basis, and based on current literature, it can be delivered more ...
Gallegos, Anthony J
core
Sex-Role Stereotypes in Medicine [PDF]
I argue for compatibility between feminism and medicine by developing a model of the physician-other relationship which is essentially egalitarian.
Mahowald, Mary B., Mary B. Mahowald
core +1 more source
Reinforcing the Foundations of Family Medicine in Egypt: Ethics, Prevention, and Patient Safety [PDF]
Family medicine plays a pivotal role in delivering comprehensive, ethical, and preventive healthcare. The studies in this issue highlight important gaps and opportunities in medical ethics, chronic disease prevention, and medication safety within ...
Nagwa Hegazy
doaj +1 more source
Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs +7 more
wiley +1 more source
The Nature and Limits of the Physician's Professional Responsibilities: Surgical Ethics, Matters of Conscience, and Managed Care [PDF]
The nature and limits of the physician's professional responsibilities constitute core topics in clinical ethics. These responsibilities originate in the physician's professional role, which was first examined in the modern English-language literature ...
McCullough, Laurence B.
core

