Results 51 to 60 of about 9,253,090 (290)

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Rubo Xing, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +16 more
wiley   +1 more source

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li, Dong‐Lin Liang, Li‐Ping Gao, Wei‐Wei Zhang, Wei Zhou, A. Ruhan, Bing Xu, Run‐Dong Cao, Kang Xiao, Cao Chen, Qi Shi, Xiao‐Ping Dong   +11 more
wiley   +1 more source

Physician's prescribing preference as an instrumental variable: exploring assumptions using survey data [PDF]

, 2015
BACKGROUND Physician's prescribing preference is increasingly used as an instrumental variable in studies of therapeutic effects. However, differences in prescribing patterns among physicians may reflect differences in preferences or in case-mix ...
le Cessie, S, Boef, AG, Schers, H, Warner, A, Kerse, Ngaire, Mallen, CD, Rosemann, T., Russell, A, Waal, M.W.M. de, Kearney, Patricia M, McCarthy, Vera J C, Boef, Anna G C, Cessie, S. le, Mooijaart, S.P., Mooijaart, SP, Russell, A., Elzen, W.P. den, Warner, A., Rodondi, Nicolas, Russell, Audrey, Mallen, Christian D, den Elzen, Wendy P J, den Elzen, WP, Mallen, C.D., Gussekloo, J, Virgini, V., Warner, Alex, Frey, Peter, Kearney, PM, Rodondi, N., Elzen, W.P.J. den, de Waal, Margot W M, McCarthy, V.J.C., Waal, M.W. de, Gussekloo, Jacobijn, Rosemann, T, Kearney, P.M., Muth, C., Kerse, N, Gussekloo, J., Rodondi, N, Schers, H., Virgini, Vanessa, Kerse, N., Virgini, V, Muth, Christiane, Rosemann, Thomas; https://orcid.org/, Frey, P., de Waal, MW, Boef, A.G.C., le Cessie, Saskia, Dekkers, O.M., Schers, H.J., Dekkers, Olaf M, Muth, C, Rosemann, Thomas, Dekkers, OM, Schers, Henk, Boef, A.G., McCarthy, VJ, Mooijaart, Simon P, McCarthy, V.J., Frey, P   +62 more
core   +2 more sources

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Dementia : Patient's Right and Physician's Role

Siriraj Medical Journal, 2003
An elderly Thai widow with progressive dementia was transferred to Siriraj Hospital for properly continued supportive treatment. Due to the course of the disease, she lacked the ability to make any valid decision related to giving consent to medical ...
Supawon Srettabunjong, Amnaj Kusalanan, Rungnirandt Praditsuwan, Chanvit Pornnoppadol   +3 more
doaj  

Lethal left cardiac thromboembolism in infant: A rare complication of pulmonary tuberculosis

Respiratory Medicine Case Reports, 2019
If acute or severe infectious are know that risk factors for venous thromboembolism (VTE), the role active tuberculosis is ill defined, despite different case reports and many small case series have proposed an association between VTE and chronic ...
N.N.M. Razafimanjato, O.A. Vita, M.R. Randriamizao, T.A. Rajaonera, F.A. Hunald, H.J.L. Rakotovao   +5 more
doaj   +1 more source

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Patient Understanding of the Resident Physician's Role in Orthopaedics

SurgiColl
# Objectives Patients at teaching hospitals interact with resident physicians, yet their understanding of residents’ roles varies. Prior studies in other specialties have found gaps in patient knowledge of the medical training hierarchy.
Jeffton Pierre, Abdulai Bangura, Lasun Oladeji, Steven DeFroda   +3 more
doaj   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source